Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), Hematology Unit, University of Palermo, Palermo, Italy.
Hematology Unit, University Hospital "Paolo Giaccone", Palermo, Italy.
Hematol Oncol. 2022 Aug;40(3):320-331. doi: 10.1002/hon.3002. Epub 2022 Apr 18.
Assessment of host-related factors is a crucial aspect in the comprehensive management of cancer patients. A distinct nutritional disturbance linked to cancer has been recognized to be associated with negative outcomes. However, compared to solid tumors, only a limited number of studies have looked specifically at nutritional issues in the field of lymphoma. The aim of this review is to integrate the current knowledge on interactions between malnutrition and lymphoma and address most relevant and pertinent questions. We first provide a literature review on the mutual biological relationship between malnutrition and lymphoma. Next, we explore the overlap between malnutrition, sarcopenia, cachexia and frailty in lymphoma studies. In addition, we summarize the clinical assessment scales used to measure malnutrition in lymphoma subjects. Furthermore, we address the problem of nutritional interventions aimed at patients who are candidates for treatment for lymphoma. Malnutrition can arise as a consequence of lymphoma disease and can in turn promote lymphomagenesis, negatively affect the response to therapy and favor adverse event to treatment. There is increasing evidence that malnutrition, sarcopenia and cachexia in lymphoma are intimately inter-related and are a hallmark of frailty. A variety of different tools are recorded with the apparent ability to describe nutritional status and to impact prognosis in lymphoma patients. Finally, a network of prognostic host- and disease-related factors is proposed where malnutrition can interact with each other in complex ways.
宿主相关因素的评估是癌症患者综合管理的关键方面。已经认识到与癌症相关的独特营养紊乱与不良结局有关。然而，与实体瘤相比，只有少数研究专门针对淋巴瘤领域的营养问题进行了研究。本综述的目的是整合营养不良和淋巴瘤之间相互作用的现有知识，并解决最相关和最相关的问题。我们首先对营养不良和淋巴瘤之间的相互生物学关系进行文献回顾。接下来，我们探讨了营养不良、肌肉减少症、恶病质和淋巴瘤研究中脆弱性之间的重叠。此外，我们总结了用于测量淋巴瘤患者营养不良的临床评估量表。此外，我们还解决了旨在为接受淋巴瘤治疗的患者进行营养干预的问题。营养不良可能是淋巴瘤疾病的结果，反过来又会促进淋巴瘤的发生，对治疗反应产生负面影响，并有利于治疗的不良事件。越来越多的证据表明，淋巴瘤中的营养不良、肌肉减少症和恶病质密切相关，是脆弱性的标志。记录了多种不同的工具，它们显然能够描述营养状况并影响淋巴瘤患者的预后。最后，提出了一个预后宿主和疾病相关因素的网络，其中营养不良可以以复杂的方式相互作用。
