Rubini Dino, Gagliardi Federico, Menditti Vittorio Salvatore, D'Ambrosio Luca, Gallo Paolo, D'Onofrio Ida, Pisani Antonio Rosario, Sardaro Angela, Rubini Giuseppe, Cappabianca Salvatore, Nardone Valerio, Reginelli Alfonso
Department of Precision Medicine, University of Campania "L. Vanvitelli", Naples, Italy.
Interdisciplinary Department of Medicine, University of Bari 'Aldo Moro', Bari, Italy.
Front Oncol. 2024 Jul 26;14:1337815. doi: 10.3389/fonc.2024.1337815. eCollection 2024.
This comprehensive review explores the pivotal role of radiotherapy in cancer treatment, emphasizing the diverse applications of genetic profiling. The review highlights genetic markers for predicting radiation toxicity, enabling personalized treatment planning. It delves into the impact of genetic profiling on radiotherapy strategies across various cancer types, discussing research findings related to treatment response, prognosis, and therapeutic resistance. The integration of genetic profiling is shown to transform cancer treatment paradigms, offering insights into personalized radiotherapy regimens and guiding decisions in cases where standard protocols may fall short. Ultimately, the review underscores the potential of genetic profiling to enhance patient outcomes and advance precision medicine in oncology.
本综述探讨了放射治疗在癌症治疗中的关键作用，强调了基因谱分析的多种应用。该综述突出了用于预测放射毒性的基因标志物，从而实现个性化治疗方案的制定。它深入研究了基因谱分析对各种癌症类型放射治疗策略的影响，讨论了与治疗反应、预后和治疗耐药性相关的研究结果。基因谱分析的整合被证明能够改变癌症治疗模式，为个性化放疗方案提供见解，并在标准方案可能不足的情况下指导决策。最终，该综述强调了基因谱分析在改善患者治疗效果和推动肿瘤学精准医学发展方面的潜力。
