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阿尔茨海默病和疑似非阿尔茨海默病病理生理学的皮质平均弥散度的时空模式。

Spatial and temporal patterns of cortical mean diffusivity in Alzheimer's disease and suspected non-Alzheimer's disease pathophysiology.

机构信息

Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China.

Tsinghua Shenzhen International Graduate School (SIGS), Tsinghua University, Shenzhen, China.

出版信息

Alzheimers Dement. 2024 Oct;20(10):7048-7061. doi: 10.1002/alz.14176. Epub 2024 Aug 12.

DOI:10.1002/alz.14176
PMID:39132849
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11485315/
Abstract

INTRODUCTION

The spatial and temporal patterns of cortical mean diffusivity (cMD), as well as its association with Alzheimer's disease (AD) and suspected non-Alzheimer's pathophysiology (SNAP), are not yet fully understood.

METHODS

We compared baseline (n = 617) and longitudinal changes (n = 421) of cMD, cortical thickness, and gray matter volume and their relations to vascular risk factors, amyloid beta (Aβ), and tau positron emission tomography (PET), and longitudinal cognitive decline in Aβ PET negative and positive older adults.

RESULTS

cMD increases were more sensitive to detecting brain structural alterations than cortical thinning and gray matter atrophy. Tau-related cMD increases partially mediated Aβ-related cognitive decline in AD, whereas vascular disease-related increased cMD levels substantially mediated age-related cognitive decline in SNAP.

DISCUSSION

These findings revealed the dynamic changes of microstructural and macrostructural indicators and their associations with AD and SNAP, providing novel insights into understanding upstream and downstream events of cMD in neurodegenerative disease.

HIGHLIGHTS

Cortical mean diffusivity (cMD) was more sensitive to detecting structural changes than macrostructural factors. Tau-related cMD increases partially mediated amyloid beta-related cognitive decline in Alzheimer's disease (AD). White matter hyperintensity-related higher cMD mainly explained the age-related cognitive decline in suspected non-Alzheimer's pathophysiology (SNAP). cMD may assist in tracking earlier neurodegenerative signs in AD and SNAP.

摘要

简介

皮质平均扩散度（cMD）的时空模式及其与阿尔茨海默病（AD）和疑似非阿尔茨海默病病理生理学（SNAP）的关系尚不完全清楚。

方法

我们比较了基线（n=617）和纵向变化（n=421）的 cMD、皮质厚度和灰质体积及其与血管危险因素、β淀粉样蛋白（Aβ）和 tau 正电子发射断层扫描（PET）的关系，以及 Aβ PET 阴性和阳性老年人的纵向认知下降。

结果

cMD 增加比皮质变薄和灰质萎缩更能敏感地检测到脑结构改变。tau 相关的 cMD 增加部分介导了 AD 中 Aβ 相关的认知下降，而血管疾病相关的 cMD 水平增加则在很大程度上介导了 SNAP 中与年龄相关的认知下降。

讨论

这些发现揭示了微观结构和宏观结构指标的动态变化及其与 AD 和 SNAP 的关系，为理解神经退行性疾病中 cMD 的上下游事件提供了新的见解。

重点

皮质平均扩散度（cMD）比宏观结构因素更能敏感地检测到结构变化。tau 相关的 cMD 增加部分介导了阿尔茨海默病（AD）中β淀粉样蛋白相关的认知下降。与脑白质高信号相关的更高的 cMD 主要解释了疑似非阿尔茨海默病病理生理学（SNAP）中与年龄相关的认知下降。cMD 可能有助于跟踪 AD 和 SNAP 中更早的神经退行性迹象。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/519b/11485315/0d800f1ea6a7/ALZ-20-7048-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/519b/11485315/b337247fbb54/ALZ-20-7048-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/519b/11485315/0d800f1ea6a7/ALZ-20-7048-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/519b/11485315/b337247fbb54/ALZ-20-7048-g006.jpg
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3
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Magn Reson Med. 2025 Sep;94(3):1166-1181. doi: 10.1002/mrm.30552. Epub 2025 Jun 4.
4
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5
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