Ou Xiangying, Yang Juan, Yang Linfeng, Zeng Huihong, Shao Lijian
Department of Occupational Health and Toxicology, Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, School of Public Health, Jiangxi Medical College, Nanchang University, Nanchang, P. R. China.
Department of Histology and Embryology, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, P. R. China.
Andrology. 2025 May;13(4):706-717. doi: 10.1111/andr.13723. Epub 2024 Aug 12.
Physical, chemical, and biological factors in the environment constantly influence in vivo and in vitro biological processes, including diverse histone modifications involved in cancer and metabolism. However, the intricate mechanisms of acetylation regulation remain poorly elucidated. In mammalian spermatogenesis, acetylation plays a crucial role in repairing double-strand DNA breaks, regulating gene transcription, and modulating various signaling pathways.
This review summarizes the histone acetylation sites in the mouse testis and provides a comprehensive overview of how histone acetylation is involved in different stages of spermatogenesis under the regulation by histone deacetylases. The regulatory functions of various class histone deacetylases during spermatogenesis and the crossroad between histone acetylation and other histone modifications are highlighted. It is imperative to understand the mechanisms of histone acetylation regulated by histone deacetylases in spermatogenesis, which facilitates to prevent and treat infertility-related diseases.
环境中的物理、化学和生物因素不断影响体内和体外的生物过程，包括参与癌症和新陈代谢的多种组蛋白修饰。然而，乙酰化调控的复杂机制仍未得到充分阐明。在哺乳动物精子发生过程中，乙酰化在修复双链DNA断裂、调节基因转录和调控各种信号通路中起着至关重要的作用。
本综述总结了小鼠睾丸中的组蛋白乙酰化位点，并全面概述了在组蛋白去乙酰化酶的调控下，组蛋白乙酰化如何参与精子发生的不同阶段。重点介绍了各种类型的组蛋白去乙酰化酶在精子发生过程中的调控功能以及组蛋白乙酰化与其他组蛋白修饰之间的交叉点。了解精子发生过程中组蛋白去乙酰化酶调控组蛋白乙酰化的机制至关重要，这有助于预防和治疗与不孕相关的疾病。
