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Oseltamivir (Tamiflu), a commonly prescribed antiviral drug, mitigates hearing loss in mice.

作者信息

Sailor-Longsworth Emma J, Lutze Richard D, Ingersoll Matthew A, Kelmann Regina G, Ly Kristina, Currier Duane, Chen Taosheng, Zuo Jian, Teitz Tal

机构信息

Department of Pharmacology and Neuroscience, School of Medicine, Creighton University, Omaha, Nebraska, USA.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

出版信息

Clin Transl Med. 2024 Aug;14(8):e1803. doi: 10.1002/ctm2.1803.

DOI:10.1002/ctm2.1803
PMID:39133201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11318337/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb4f/11318337/ba0c84bc8f24/CTM2-14-e1803-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb4f/11318337/ded3f5dd1e12/CTM2-14-e1803-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb4f/11318337/9ed7f066313e/CTM2-14-e1803-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb4f/11318337/bf542ad633a8/CTM2-14-e1803-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb4f/11318337/ba0c84bc8f24/CTM2-14-e1803-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb4f/11318337/ded3f5dd1e12/CTM2-14-e1803-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb4f/11318337/9ed7f066313e/CTM2-14-e1803-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb4f/11318337/bf542ad633a8/CTM2-14-e1803-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb4f/11318337/ba0c84bc8f24/CTM2-14-e1803-g002.jpg

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1
Oseltamivir (Tamiflu), a commonly prescribed antiviral drug, mitigates hearing loss in mice.常用的抗病毒药物奥司他韦(达菲)可减轻小鼠的听力损失。
Clin Transl Med. 2024 Aug;14(8):e1803. doi: 10.1002/ctm2.1803.
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Oseltamivir (Tamiflu), a Commonly Prescribed Antiviral Drug, Mitigates Hearing Loss in Mice.常用抗病毒药物奥司他韦(达菲)可减轻小鼠听力损失。
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本文引用的文献

1
Dabrafenib protects from cisplatin-induced hearing loss in a clinically relevant mouse model.达巴非尼可预防临床相关的小鼠模型中顺铂诱导的听力损失。
JCI Insight. 2023 Dec 22;8(24):e171140. doi: 10.1172/jci.insight.171140.
2
Sodium Thiosulfate: Pediatric First Approval.硫代硫酸钠:儿科首次批准。
Paediatr Drugs. 2023 Mar;25(2):239-244. doi: 10.1007/s40272-022-00550-x.
3
SuperPred 3.0: drug classification and target prediction-a machine learning approach.SuperPred 3.0:药物分类和靶标预测——一种机器学习方法。
Nucleic Acids Res. 2022 Jul 5;50(W1):W726-W731. doi: 10.1093/nar/gkac297.
4
BRAF inhibition protects against hearing loss in mice.BRAF 抑制可预防小鼠听力损失。
Sci Adv. 2020 Dec 2;6(49). doi: 10.1126/sciadv.abd0561. Print 2020 Dec.
5
An optimized, clinically relevant mouse model of cisplatin-induced ototoxicity.顺铂诱导耳毒性的优化、临床相关的小鼠模型。
Hear Res. 2019 Apr;375:66-74. doi: 10.1016/j.heares.2019.02.006. Epub 2019 Feb 22.
6
CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss.CDK2 抑制剂作为顺铂和噪声性听力损失的候选治疗药物。
J Exp Med. 2018 Apr 2;215(4):1187-1203. doi: 10.1084/jem.20172246. Epub 2018 Mar 7.
7
Development of Cell-Based High-Throughput Chemical Screens for Protection Against Cisplatin-Induced Ototoxicity.用于预防顺铂诱导耳毒性的基于细胞的高通量化学筛选方法的开发
Methods Mol Biol. 2016;1427:419-30. doi: 10.1007/978-1-4939-3615-1_22.
8
A simple practice guide for dose conversion between animals and human.动物与人之间剂量转换的简易实践指南。
J Basic Clin Pharm. 2016 Mar;7(2):27-31. doi: 10.4103/0976-0105.177703.
9
Pharmacokinetics of oseltamivir: an oral antiviral for the treatment and prophylaxis of influenza in diverse populations.奥司他韦的药代动力学:一种用于治疗和预防不同人群流感的口服抗病毒药物。
J Antimicrob Chemother. 2010 Apr;65 Suppl 2(Suppl 2):ii5-ii10. doi: 10.1093/jac/dkq015.
10
Limited inhibitory effects of oseltamivir and zanamivir on human sialidases.奥司他韦和扎那米韦对人唾液酸酶的抑制作用有限。
Antimicrob Agents Chemother. 2008 Oct;52(10):3484-91. doi: 10.1128/AAC.00344-08. Epub 2008 Aug 11.