Yan L, Xiong H, Long F, Chen Z, Wang Z, Yang L, Tao F, Chen Y, Song N, Wu M
Laboratory of Pediatric Hematology, Wuhan Children's Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China.
Laboratory of Pediatric Hematology, Wuhan Children's Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China Department of Hematology, Wuhan Children's Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China.
Zhonghua Xue Ye Xue Za Zhi. 2024 Jun 14;45(6):586-590. doi: 10.3760/cma.j.cn121090-20231214-00310.
This study aimed to investigate the effect of iron overload on the transplant outcomes of pediatric patients with severe aplastic anemia (SAA) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). A retrospective analysis was conducted on the clinical data of 74 children with SAA who received allo-HSCT at the Hematology Department of Wuhan Children's Hospital between January 2018 and August 2022. Children with iron overload (serum ferritin >1 000 μg/L) before transplantation had a longer disease course, received more red blood cell transfusions, and had a higher number of CD34(+) cells infused. Moreover, iron overload significantly delayed the reconstitution of regulatory T cells after transplantation, increasing the incidence of hemorrhagic cystitis and grade Ⅲ-Ⅳ acute graft-versus-host disease after transplantation. However, iron overload did not significantly affect the overall survival and failure-free survival rates of the children.
本研究旨在探讨铁过载对接受异基因造血干细胞移植（allo-HSCT）的重型再生障碍性贫血（SAA）患儿移植结局的影响。对2018年1月至2022年8月期间在武汉市儿童医院血液科接受allo-HSCT的74例SAA患儿的临床资料进行回顾性分析。移植前存在铁过载（血清铁蛋白>1000μg/L）的患儿病程较长，接受红细胞输注次数较多，输注的CD34(+)细胞数量较多。此外，铁过载显著延迟了移植后调节性T细胞的重建，增加了移植后出血性膀胱炎和Ⅲ-Ⅳ级急性移植物抗宿主病的发生率。然而，铁过载对患儿的总生存率和无失败生存率无显著影响。
