[Research progress of characteristics and mechanisms of iron overload affecting bone marrow hematopoiesis].
作者信息
Huang L, Fu R
机构信息
Department of Hematology, General Hospital, Tianjin Medical University, Tianjin 300052, China.
出版信息
Zhonghua Xue Ye Xue Za Zhi. 2019 Aug 14;40(8):709-712. doi: 10.3760/cma.j.issn.0253-2727.2019.08.021.
Abstract
摘要
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Iron overload impairs normal hematopoietic stem and progenitor cells through reactive oxygen species and shortens survival in myelodysplastic syndrome mice.铁过载通过活性氧物种损害正常造血干/祖细胞，并缩短骨髓增生异常综合征小鼠的存活时间。
Haematologica. 2018 Oct;103(10):1627-1634. doi: 10.3324/haematol.2018.193128. Epub 2018 Jun 14.
2
Comparison of the effects of deferasirox, deferoxamine, and combination of deferasirox and deferoxamine on an aplastic anemia mouse model complicated with iron overload.地拉罗司、去铁胺以及地拉罗司与去铁胺联合用药对合并铁过载的再生障碍性贫血小鼠模型的影响比较
Drug Des Devel Ther. 2018 May 3;12:1081-1091. doi: 10.2147/DDDT.S161086. eCollection 2018.
3
Iron overload promotes mitochondrial fragmentation in mesenchymal stromal cells from myelodysplastic syndrome patients through activation of the AMPK/MFF/Drp1 pathway.铁过载通过激活 AMPK/MFF/Drp1 通路促进骨髓增生异常综合征患者间充质基质细胞的线粒体碎片化。
Cell Death Dis. 2018 May 1;9(5):515. doi: 10.1038/s41419-018-0552-7.
4
Prospective evaluation of the effect of deferasirox on hematologic response in transfusion-dependent patients with low-risk MDS and iron overload.去铁胺对低危骨髓增生异常综合征及铁过载的输血依赖患者血液学反应影响的前瞻性评估
Eur J Haematol. 2018 May 2. doi: 10.1111/ejh.13088.
5
Reactive oxygen species levels control NF-κB activation by low dose deferasirox in erythroid progenitors of low risk myelodysplastic syndromes.活性氧水平通过低剂量地拉罗司控制低危骨髓增生异常综合征红系祖细胞中NF-κB的激活。
Oncotarget. 2017 Nov 6;8(62):105510-105524. doi: 10.18632/oncotarget.22299. eCollection 2017 Dec 1.
6
Inhibition of heme oxygenase ameliorates anemia and reduces iron overload in a β-thalassemia mouse model.血红素加氧酶抑制可改善β-地中海贫血小鼠模型的贫血并减少铁过载。
Blood. 2018 Jan 11;131(2):236-246. doi: 10.1182/blood-2017-07-798728. Epub 2017 Nov 27.
7
Heme oxygenase-1 protects bone marrow mesenchymal stem cells from iron overload through decreasing reactive oxygen species and promoting IL-10 generation.血红素加氧酶-1 通过减少活性氧和促进白细胞介素-10 的产生来保护骨髓间充质干细胞免受铁过载的影响。
Exp Cell Res. 2018 Jan 1;362(1):28-42. doi: 10.1016/j.yexcr.2017.10.029. Epub 2017 Oct 28.
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