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Zhonghua Xue Ye Xue Za Zhi. 2014 Nov;35(11):1000-4. doi: 10.3760/cma.j.issn.0253-2727.2014.11.011.
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ROS-mediated iron overload injures the hematopoiesis of bone marrow by damaging hematopoietic stem/progenitor cells in mice.活性氧介导的铁过载通过损伤小鼠造血干/祖细胞来损害骨髓造血。
Sci Rep. 2015 May 13;5:10181. doi: 10.1038/srep10181.
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[Establishment of an mouse model of iron-overload and its impact on bone marrow hematopoiesis].[铁过载小鼠模型的建立及其对骨髓造血的影响]
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2013 Oct;35(5):547-52. doi: 10.3881/j.issn.1000-503X.2013.05.012.
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[Impacts of iron overload on hematopoiesis and its microenvironment].[铁过载对造血及其微环境的影响]
Rinsho Ketsueki. 2015 Jun;56(6):577-85. doi: 10.11406/rinketsu.56.577.
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The role of T2*-weighted gradient echo in the diagnosis of tumefactive intrahepatic extramedullary hematopoiesis in myelodysplastic syndrome and diffuse hepatic iron overload: a case report and review of the literature.T2*加权梯度回波在骨髓增生异常综合征中瘤样肝内髓外造血及弥漫性肝铁过载诊断中的作用：一例报告并文献复习
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The bone marrow hematopoietic microenvironment is impaired in iron-overloaded mice.铁过载小鼠的骨髓造血微环境受损。
Eur J Haematol. 2014 Aug;93(2):118-28. doi: 10.1111/ejh.12309. Epub 2014 Mar 28.
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[In vitro effect of iron overload on bone marrow cell function by inducing the reactive oxygen species].铁过载通过诱导活性氧对骨髓细胞功能的体外影响
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[Establishment of iron overloaded bone marrow model in vitro and its impact on hematopoiesis].[体外铁过载骨髓模型的建立及其对造血的影响]
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Aug;19(4):1038-42.

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[Clinical analysis on the impact of pretransplant iron overload on allogeneic hematopoietic stem cell transplantation for patients with acquired severe aplastic anemia in pediatric].[移植前铁过载对小儿获得性重型再生障碍性贫血患者异基因造血干细胞移植影响的临床分析]
Zhonghua Xue Ye Xue Za Zhi. 2024 Jun 14;45(6):586-590. doi: 10.3760/cma.j.cn121090-20231214-00310.

本文引用的文献

1
Iron overload impairs normal hematopoietic stem and progenitor cells through reactive oxygen species and shortens survival in myelodysplastic syndrome mice.铁过载通过活性氧物种损害正常造血干/祖细胞，并缩短骨髓增生异常综合征小鼠的存活时间。
Haematologica. 2018 Oct;103(10):1627-1634. doi: 10.3324/haematol.2018.193128. Epub 2018 Jun 14.
2
Comparison of the effects of deferasirox, deferoxamine, and combination of deferasirox and deferoxamine on an aplastic anemia mouse model complicated with iron overload.地拉罗司、去铁胺以及地拉罗司与去铁胺联合用药对合并铁过载的再生障碍性贫血小鼠模型的影响比较
Drug Des Devel Ther. 2018 May 3;12:1081-1091. doi: 10.2147/DDDT.S161086. eCollection 2018.
3
Iron overload promotes mitochondrial fragmentation in mesenchymal stromal cells from myelodysplastic syndrome patients through activation of the AMPK/MFF/Drp1 pathway.铁过载通过激活 AMPK/MFF/Drp1 通路促进骨髓增生异常综合征患者间充质基质细胞的线粒体碎片化。
Cell Death Dis. 2018 May 1;9(5):515. doi: 10.1038/s41419-018-0552-7.
4
Prospective evaluation of the effect of deferasirox on hematologic response in transfusion-dependent patients with low-risk MDS and iron overload.去铁胺对低危骨髓增生异常综合征及铁过载的输血依赖患者血液学反应影响的前瞻性评估
Eur J Haematol. 2018 May 2. doi: 10.1111/ejh.13088.
5
Reactive oxygen species levels control NF-κB activation by low dose deferasirox in erythroid progenitors of low risk myelodysplastic syndromes.活性氧水平通过低剂量地拉罗司控制低危骨髓增生异常综合征红系祖细胞中NF-κB的激活。
Oncotarget. 2017 Nov 6;8(62):105510-105524. doi: 10.18632/oncotarget.22299. eCollection 2017 Dec 1.
6
Inhibition of heme oxygenase ameliorates anemia and reduces iron overload in a β-thalassemia mouse model.血红素加氧酶抑制可改善β-地中海贫血小鼠模型的贫血并减少铁过载。
Blood. 2018 Jan 11;131(2):236-246. doi: 10.1182/blood-2017-07-798728. Epub 2017 Nov 27.
7
Heme oxygenase-1 protects bone marrow mesenchymal stem cells from iron overload through decreasing reactive oxygen species and promoting IL-10 generation.血红素加氧酶-1 通过减少活性氧和促进白细胞介素-10 的产生来保护骨髓间充质干细胞免受铁过载的影响。
Exp Cell Res. 2018 Jan 1;362(1):28-42. doi: 10.1016/j.yexcr.2017.10.029. Epub 2017 Oct 28.
8
Serum ferritin is a different predictor from transfusion history for allogeneic transplantation outcome in patients with severe aplastic anemia.对于重型再生障碍性贫血患者，血清铁蛋白是与同种异体移植结局相关的不同于输血史的预测指标。
Hematology. 2018 Jun;23(5):291-298. doi: 10.1080/10245332.2017.1390929. Epub 2017 Oct 18.
9
Intracellular iron overload leading to DNA damage of lymphocytes and immune dysfunction in thalassemia major patients.地中海贫血症患者的淋巴细胞内铁过载导致 DNA 损伤和免疫功能障碍。
Eur J Haematol. 2017 Nov;99(5):399-408. doi: 10.1111/ejh.12936. Epub 2017 Sep 13.
10
Transferrin saturation concentrations associated with telomeric ageing: a population-based study.与端粒衰老相关的转铁蛋白饱和度浓度：一项基于人群的研究。
Br J Nutr. 2017 Jun;117(12):1693-1701. doi: 10.1017/S0007114517001696. Epub 2017 Jul 19.

[Research progress of characteristics and mechanisms of iron overload affecting bone marrow hematopoiesis].

作者信息

Huang L, Fu R

机构信息

Department of Hematology, General Hospital, Tianjin Medical University, Tianjin 300052, China.

出版信息

Zhonghua Xue Ye Xue Za Zhi. 2019 Aug 14;40(8):709-712. doi: 10.3760/cma.j.issn.0253-2727.2019.08.021.

DOI:10.3760/cma.j.issn.0253-2727.2019.08.021
PMID:31495147
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7342874/
Abstract
摘要