[采用改良MINE方案治疗侵袭性NK细胞白血病和T细胞淋巴瘤继发噬血细胞综合征：三例报告及文献复习]
[Hemophagocytic syndrome secondary to invasive NK cell leukemia and T-cell lymphoma treated with the modified MINE protocol: report of three cases and literature review].
作者信息
Wu D, Li M J, Li Y, Lu T X, Fu L Y, He P C
机构信息
Department of Hematology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Department of Hematology and Oncology, Nuclear Industry 417 Hospital, Xi'an 710600, China.
出版信息
Zhonghua Xue Ye Xue Za Zhi. 2024 Jun 14;45(6):599-601. doi: 10.3760/cma.j.cn121090-20231115-00261.
Abstract
Lymphoma-associated hemophagocytic syndrome is aggressive with rapid progression, particularly in NK/T cell lymphoma. The MINE regimen is a salvage treatment for aggressive non-Hodgkin lymphoma. In our center, the modified MINE regimen was applied to treat three patients with hemophagocytic syndrome secondary to aggressive NK cell leukemia and T-cell lymphoma. The modified MINE regimen showed good efficacy against NK/T cell lymphoma, control of the inflammatory state of secondary hemophagocytic syndrome, and good tolerability.
摘要
淋巴瘤相关噬血细胞综合征进展迅速，病情凶险，尤其在NK/T细胞淋巴瘤中。MINE方案是侵袭性非霍奇金淋巴瘤的挽救治疗方案。在我们中心，采用改良MINE方案治疗3例继发于侵袭性NK细胞白血病和T细胞淋巴瘤的噬血细胞综合征患者。改良MINE方案对NK/T细胞淋巴瘤显示出良好疗效，能控制继发噬血细胞综合征的炎症状态，且耐受性良好。
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