Department of Pediatrics, Division of Neonatology, Istanbul Medeniyet University Goztepe Prof. Dr. Suleyman Yalcın City Hospital, Istanbul, Turkey.
Department of Biostatistics and Medical Informatics, Istanbul Medeniyet University Goztepe Prof. Dr. Suleyman Yalcın City Hospital, Istanbul, Turkey.
J Perinatol. 2024 Nov;44(11):1675-1681. doi: 10.1038/s41372-024-02081-4. Epub 2024 Aug 12.
To investigate the effects of breast milk on cortical pain response and behavioral response in newborns during heel-prick procedure.
A prospective, randomized controlled trial was conducted on healty-term newborns, undergoing heel blood sampling. Infants were randomly assigned to study group with receive orally 2 ml breast milk (n = 45) or a control group with no intervention (n = 45). A near-infrared spectroscopy device was used to monitor regional cerebral oxygen saturation (rScO), while neonatal pain expression was assessed by Neonatal Pain, Agitation, and Sedation Scale (N-PASS).
The N-PASS score (p = 0.001) and the crying time (p = 0.017) were significantly lower in the study group compared to the control group. Although the mean rScO values decreased in both groups during the procedure, the percent change in rScO was not significant difference between two groups.
Breast milk administration decreases behavioral responses to a noxious stimulus without reducing the cortical response to pain.
This trial was registered under ClinicalTrials.gov identifier no. NCT05961904.
研究母乳喂养对足跟采血新生儿皮质疼痛反应和行为反应的影响。
对行足跟血样采集的健康足月新生儿进行前瞻性、随机对照试验。将婴儿随机分为研究组（口服 2ml 母乳）（n=45）或对照组（无干预）（n=45）。使用近红外光谱仪监测局部脑氧饱和度（rScO），同时使用新生儿疼痛、躁动和镇静评分（N-PASS）评估新生儿疼痛表现。
与对照组相比，研究组的 N-PASS 评分（p=0.001）和哭泣时间（p=0.017）显著降低。尽管两组在操作过程中 rScO 值均降低，但两组间 rScO 的变化百分比无显著差异。
母乳喂养可降低新生儿对有害刺激的行为反应，而不降低皮质对疼痛的反应。
本试验在 ClinicalTrials.gov 标识符 NCT05961904 下注册。
