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氧化锌纳米颗粒通过炎症反应以及降低成年雄性大鼠的睾酮水平和细胞活力诱导睾丸毒性。

Zinc Oxide Nanoparticles Induced Testicular Toxicity Through Inflammation and Reducing Testosterone and Cell Viability in Adult Male Rats.

作者信息

Ahmed Dina H, El-Beih Nadia M, El-Hussieny Enas A, El-Sayed Wael M

机构信息

Department of Zoology, Faculty of Science, Ain Shams University, Abbassia, 11566, Cairo, Egypt.

出版信息

Biol Trace Elem Res. 2025 Apr;203(4):1934-1948. doi: 10.1007/s12011-024-04330-1. Epub 2024 Aug 12.

DOI:10.1007/s12011-024-04330-1
PMID:39134772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11919946/
Abstract

Zinc oxide nanoparticles (ZnO NPs) have wide applications in daily life. Therefore, there is growing interest in the potential harmful impacts of these particles on human health. The present study was conducted to investigate the potential toxic effects of ZnO NPs (40 and 70 nm) compared to ZnO on the testes of rats. ZnO NPs were synthesized and characterized by transmission electron microscopy (TEM) and X-ray diffraction (XRD). Adult male rats were randomly divided into four groups (n = 8): Group I (control), Group II (ZnO) received daily oral administration of ZnO (50 mg/kg), and Groups III and IV received daily oral administration of ZnO NPs of 40 nm or 70 nm at 50 mg/kg, respectively. All treatments continued for 50 consecutive days. ZnO and ZnO NPs reduced body and testis weights, sperm count and motility, serum luteinizing hormone (LH) and testosterone levels, testicular cytochrome p450 17A1 (CYP17A1) and cytochrome p450 1B1 (CYP1B1) concentrations, and the expression of p53 and cdk1. These treatments elevated testicular myeloperoxidase and serum acid phosphatase activities as well as sperm abnormalities. ZnO NPs reduced LH levels, which decreased CYP17A1 and CYP1B1, resulting in reduced synthesis of testosterone. ZnO NPs enhanced testicular inflammation and reduced cell viability. All these effects were manifested as reduced sperm motility and increased sperm deformities. Compared to macromolecules, nanoparticles exhibited significantly higher toxicity. The larger diameter ZnO NPs had more profound toxicity than the smaller-sized particles.

摘要

氧化锌纳米颗粒（ZnO NPs）在日常生活中有广泛应用。因此，人们越来越关注这些颗粒对人类健康的潜在有害影响。本研究旨在调查与氧化锌相比，ZnO NPs（40和70纳米）对大鼠睾丸的潜在毒性作用。通过透射电子显微镜（TEM）和X射线衍射（XRD）对ZnO NPs进行了合成和表征。成年雄性大鼠随机分为四组（n = 8）：第一组（对照组），第二组（ZnO组）每天口服氧化锌（50毫克/千克），第三组和第四组分别每天口服50毫克/千克的40纳米或70纳米的ZnO NPs。所有处理持续50天。氧化锌和ZnO NPs降低了体重和睾丸重量、精子数量和活力、血清促黄体生成素（LH）和睾酮水平、睾丸细胞色素p450 17A1（CYP17A1）和细胞色素p450 1B1（CYP1B1）浓度以及p53和cdk1的表达。这些处理提高了睾丸髓过氧化物酶和血清酸性磷酸酶活性以及精子异常率。ZnO NPs降低了LH水平，进而降低了CYP17A1和CYP1B1，导致睾酮合成减少。ZnO NPs加剧了睾丸炎症并降低了细胞活力。所有这些影响表现为精子活力降低和精子畸形增加。与大分子相比，纳米颗粒表现出明显更高的毒性。直径较大的ZnO NPs比较小尺寸的颗粒毒性更强。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bf0/11919946/eb060ccd79d0/12011_2024_4330_Fig10_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bf0/11919946/eb060ccd79d0/12011_2024_4330_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bf0/11919946/15786e7d2c49/12011_2024_4330_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bf0/11919946/fa760a7241bb/12011_2024_4330_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bf0/11919946/9dbc54733ed6/12011_2024_4330_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bf0/11919946/6dee20e586c1/12011_2024_4330_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bf0/11919946/4b3023ce19d2/12011_2024_4330_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bf0/11919946/15223d98ceb0/12011_2024_4330_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bf0/11919946/8dbe4526aec9/12011_2024_4330_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bf0/11919946/04038e1881fb/12011_2024_4330_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bf0/11919946/9052949fe8e5/12011_2024_4330_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bf0/11919946/eb060ccd79d0/12011_2024_4330_Fig10_HTML.jpg

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引用本文的文献

[1]
The dual effects of nanomaterials on sperm and seminal fluid oxidative stress.

Mater Today Bio. 2025-8-5

[2]
10-Hydroxy Decanoic Acid and Zinc Oxide Nanoparticles Retrieve Nrf2/HO-1 and Caspase-3/Bax/Bcl-2 Signaling in Lead-Induced Testicular Toxicity.

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本文引用的文献

[1]
Vitamins A, C, and E Exert Anti-apoptotic Function in the Testis of Rats After Exposure to Zinc Oxide Nanoparticles.

Chonnam Med J. 2023-1

[2]
Exposure to zinc oxide nanoparticles affects testicular structure, reproductive development and spermatogenesis in parental and offspring male rats.

Ann Transl Med. 2022-7

[3]
The effects of age on sperm quality: an evaluation of 1,500 semen samples.

JBRA Assist Reprod. 2014-6-27

[4]
Histological and biochemical apoptosis changes of female rats' ovary by Zinc oxide nanoparticles and potential protective effects of l-arginine: An experimental study.

Ann Med Surg (Lond). 2022-1-30

[5]
In vitro investigation of zinc oxide nanoparticle toxic effects in spermatogonial cells at the molecular level.

Chem Biol Interact. 2022-1-5

[6]
Protective effects of green and chemical zinc oxide nanoparticles on testis histology, sperm parameters, oxidative stress markers and androgen production in rats treated with cisplatin.

Cell Tissue Res. 2021-5

[7]
Insight Study on the Comparison between Zinc Oxide Nanoparticles and Its Bulk Impact on Reproductive Performance, Antioxidant Levels, Gene Expression, and Histopathology of Testes in Male Rats.

Antioxidants (Basel). 2020-12-31

[8]
Reproductive organ dysfunction and gene expression after orally administration of ZnO nanoparticles in murine.

Environ Toxicol. 2021-4

[9]
Taurine abates the liver damage induced by γ-irradiation in rats through anti-inflammatory and anti-apoptotic pathways.

Int J Radiat Biol. 2020-12

[10]
Myeloperoxidase: Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases.

Pharmacol Ther. 2021-2

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