Burke Shanna L, Grudzien Adrienne, Li Tan, Garcia Stephanie, Martinez Sabrina Sales, Jurich Emily, Jimenez Daniel R, Hernández Jacqueline, Liu Qingyun, Tyrell Tahirah A, Campa Adriana L, Johnson Anglique, Bursac Zoran, Baum Marianna K
School of Social Work, Robert Stempel College of Public Health and Social Work, Florida International University, 11200 SW 8th St., AHC5, Miami, FL, 33199, USA.
Community-Based Research Institute, Florida International University, 11200 SW 8th St. AHC5, Miami, FL, 33199, USA.
J Neurovirol. 2024 Dec;30(5-6):500-512. doi: 10.1007/s13365-024-01225-8. Epub 2024 Aug 12.
The impact of APOE on HIV and HCV disease course, cognition, and memory has been understudied in minoritized populations. This study examined whether scores on cognition and depression measures differed by APOE ε4 carrier status while considering HCV and HIV seropositivity and whether these measures were moderated by substance use. A retrospective analysis examined cognitive and psychological data from participants (n = 493) in the Miami Adult Studies on HIV (MASH) cohort. APOE genotyping was performed on banked blood samples. Multiple linear regression was employed to examine differences across participants living with and without HIV and/or HCV and by APOE ε4 genotype. APOE ε4 carriers living with HCV who used cannabis had higher depression scores than non-ε4 carriers, while nonusers had fewer depressive symptoms. APOE ε4 carriers living with HCV had better cognition scores after adjusting for cocaine, opiate, and cannabis use than non-ε4 carriers. Scores on cognitive and depression measures did not differ between APOE ε4 carriers and non-ε4 carriers in participants living with HIV, and substance use did not moderate this relationship. This study was the first of its kind to examine substance use as a moderator for cognition and depression among individuals with HIV and/or HCV stratified by APOE genotype. Findings support further research evaluating the frequency and duration of 1) domains of cognitive functioning impacted by APOE genotype relevant to substance use and 2) the influence of substance use on cognitive and depressive outcomes among adults living with HIV and HCV, HIV, or HCV.
在少数族裔人群中，APOE对HIV和HCV病程、认知及记忆的影响尚未得到充分研究。本研究探讨了在考虑HCV和HIV血清阳性的情况下，认知和抑郁测量得分是否因APOE ε4携带者状态而异，以及这些测量是否受物质使用的调节。一项回顾性分析检查了迈阿密成人HIV研究（MASH）队列中参与者（n = 493）的认知和心理数据。对储存的血液样本进行APOE基因分型。采用多元线性回归分析来研究感染和未感染HIV和/或HCV的参与者之间以及APOE ε4基因型之间的差异。携带APOE ε4且感染HCV并使用大麻的参与者比非ε4携带者有更高的抑郁得分，而不使用者的抑郁症状较少。在调整可卡因、阿片类药物和大麻使用情况后，携带APOE ε4且感染HCV的参与者比非ε4携带者有更好的认知得分。在感染HIV的参与者中，APOE ε4携带者和非ε4携带者在认知和抑郁测量得分上没有差异，物质使用也未调节这种关系。本研究首次在按APOE基因型分层的HIV和/或HCV感染者中，将物质使用作为认知和抑郁的调节因素进行研究。研究结果支持进一步开展研究，评估1）与物质使用相关的、受APOE基因型影响的认知功能领域，以及2）物质使用对感染HIV和HCV、HIV或HCV的成年人认知和抑郁结果的影响的频率和持续时间。
