Student Research Committee, Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
BMC Cancer. 2024 Aug 12;24(1):995. doi: 10.1186/s12885-024-12769-7.
Dietary potassium can play an important role in decreasing inflammatory factors as a protective factor for cancers. In this case-control study, we aimed to assess the possible association between dietary potassium intake and the risk of breast cancer (BC) among Iranian adult women.
The present case-control study was conducted at Shohada and Imam Hossain hospitals, in Tehran. The study included 134 newly diagnosed cases of BC and 267 controls. A validated semi-quantitative 168-item food frequency questionnaire was used to compute the potassium intake. Logistic regression, adjusted for potential confounders, was used to estimate odds ratios(ORs) and 95% confidence intervals(CI) of BC according to tertiles of potassium intake.
The mean(M) ± standard deviation(SD) of age and body mass index (BMI) were 47.9 ± 10.3 years and 29.4 ± 5.5 kg/m, respectively. Also, the M ± SD of potassium intake for the control and case groups was 1616 ± 293 and 1542 ± 338 (mg/1000 Kcal), respectively. In the multivariable-adjusted model for potential confounders, the higher total potassium intake was associated with decreased odds of BC (OR: 0.35, 95%CI: 0.19-0.62, P for trend < 0.001). Moreover, an inverse relationship was observed between potassium from plant sources (OR: 0.39, 95%CI: 0.22-0.69, P for trend = 0.001) and fruit and vegetable sources (OR: 0.49, 95%CI: 0.28-0.87, P for trend = 0.016) and odds of BC.
Our findings suggested that diet rich in potassium may have a predictive role to reduce the odds of BC.
膳食钾作为癌症的保护因素，可以在降低炎症因子方面发挥重要作用。在这项病例对照研究中，我们旨在评估伊朗成年女性膳食钾摄入量与乳腺癌（BC）风险之间的可能关联。
本病例对照研究在德黑兰的 Shohada 和 Imam Hossain 医院进行。研究纳入了 134 例新诊断的 BC 病例和 267 例对照。使用经过验证的半定量 168 项食物频率问卷来计算钾摄入量。采用多变量调整潜在混杂因素的逻辑回归，估计钾摄入量三分位组的 BC 比值比（OR）和 95%置信区间（CI）。
年龄和体重指数（BMI）的平均值（M）±标准差（SD）分别为 47.9±10.3 岁和 29.4±5.5kg/m2。此外，对照组和病例组的钾摄入量 M±SD 分别为 1616±293 和 1542±338（mg/1000Kcal）。在多变量调整潜在混杂因素的模型中，较高的总钾摄入量与 BC 的较低几率相关（OR：0.35，95%CI：0.19-0.62，P 趋势<0.001）。此外，植物来源的钾（OR：0.39，95%CI：0.22-0.69，P 趋势=0.001）与水果和蔬菜来源的钾（OR：0.49，95%CI：0.28-0.87，P 趋势=0.016）与 BC 的几率呈负相关。
我们的研究结果表明，富含钾的饮食可能具有预测作用，可以降低 BC 的几率。
