The Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou, Changzhou, China.
State Key Laboratory of Cardiovascular Diseases, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Aging Cell. 2024 Oct;23(10):e14309. doi: 10.1111/acel.14309. Epub 2024 Aug 12.
Atrial fibrillation (AF) has been receiving a lot of attention from scientists and clinicians because it is an extremely common clinical condition. Due to its special hemodynamic changes, AF has a high rate of disability and mortality. So far, although AF has some therapeutic means, it is still an incurable disease because of its complex risk factors and pathophysiologic mechanisms, which is a difficult problem for global public health. Age is an important independent risk factor for AF, and the incidence of AF increases with age. To date, there is no comprehensive review on aging-associated AF. In this review, we systematically discuss the pathophysiologic evidence for aging-associated AF, and in particular explore the pathophysiologic mechanisms of mitochondrial dysfunction, telomere attrition, cellular senescence, disabled macroautophagy, and gut dysbiosis involved in recent studies with aging-associated AF. We hope that by exploring the various dimensions of aging-associated AF, we can better understand the specific relationship between age and AF, which may be crucial for innovative treatments of aging-associated AF.
心房颤动（AF）一直受到科学家和临床医生的关注，因为它是一种极其常见的临床病症。由于其特殊的血液动力学变化，AF 的致残率和死亡率很高。到目前为止，尽管 AF 有一些治疗手段，但由于其复杂的危险因素和病理生理机制，它仍然是一种无法治愈的疾病，这是一个全球性的公共卫生难题。年龄是 AF 的一个重要独立危险因素，AF 的发病率随着年龄的增长而增加。迄今为止，尚无关于与年龄相关的 AF 的综合综述。在这篇综述中，我们系统地讨论了与年龄相关的 AF 的病理生理证据，并特别探讨了与年龄相关的 AF 中涉及的线粒体功能障碍、端粒磨损、细胞衰老、失能巨自噬和肠道菌群失调的病理生理机制。我们希望通过探索与年龄相关的 AF 的各个方面，能够更好地理解年龄与 AF 之间的具体关系，这对于与年龄相关的 AF 的创新性治疗可能至关重要。
