Qingpu Traditional Chinese Medicine Hospital, Shanghai, China.
Fudan University, Shanghai, China.
Integr Cancer Ther. 2024 Jan-Dec;23:15347354241269898. doi: 10.1177/15347354241269898.
Cancer and psychiatric symptoms are associated. Fear of cancer recurrence (FCR) is the most common psychological problem for cancer survivors. Pharmacological interventions can help, but also have major drawbacks. Music therapy and music interventions have been shown to be a safe and practical complementary treatment. This randomized, controlled trial aimed to investigate the effects of music therapy and music intervention in attenuating non-small cell lung cancer (NSCLC) patients' anxiety related to FCR. NSCLC patients with FCR were randomly allocated to a music therapy and intervention group (G1) and Control group (G2). Patients' anxiety was measured using the State-Trait Anxiety Inventory scores and heart rates. Primary outcome measure were PET scans. Secondary measures were salivary cortisol, salivary α-amylase levels and heart rate. Patients in G1 showed higher glucose metabolism of F-FDG in the superior frontal gyrus, anterior cingulate, superior temporal gyrus, and parahippocampal gyrus, compared to those in G2 (all < .001). Heart rates and salivary α-amylase area under the curve (AUC) and relative variation (VAR) in G1 were significantly lower than those in G2 (all < .05). State-Trait Anxiety Inventory scores and cortisol AUC in G1 were significantly lower than those in G2 (all < .05). Music therapy and interventions can reduce anxiety and endocrinological responses and change glucose metabolism of F-FDG in fear-related brain regions.Trial registration: Registered retrospectively, ISRCTN Registry, www.isrctn.com, ISRCTN23276302Clinical Implications: Cancer treatment centers and physical examination centers should consider providing music therapy and intervention to the appropriate patients as a routine component of a comprehensive clinical care during medical examinations.
癌症与精神症状相关。对癌症复发的恐惧（FCR）是癌症幸存者最常见的心理问题。药物干预可能会有所帮助，但也存在重大缺陷。音乐疗法和音乐干预已被证明是一种安全且实用的补充治疗方法。 这项随机对照试验旨在研究音乐疗法和音乐干预在减轻非小细胞肺癌（NSCLC）患者对 FCR 的焦虑中的作用。 将 FCR 的 NSCLC 患者随机分配到音乐治疗和干预组（G1）和对照组（G2）。使用状态特质焦虑量表评分和心率测量患者的焦虑。主要观察指标为 PET 扫描。次要观察指标为唾液皮质醇、唾液α-淀粉酶水平和心率。与 G2 相比，G1 组患者额上回、前扣带回、颞上回和海马旁回的 F-FDG 葡萄糖代谢更高（均 P <.001）。G1 组的心率和唾液α-淀粉酶曲线下面积（AUC）和相对变化（VAR）明显低于 G2 组（均 P <.05）。G1 组的状态特质焦虑量表评分和皮质醇 AUC 明显低于 G2 组（均 P <.05）。 音乐疗法和干预可以降低焦虑和内分泌反应，并改变与恐惧相关的大脑区域的 F-FDG 葡萄糖代谢。 试验注册：回顾性注册，ISRCTN 注册处，www.isrctn.com，ISRCTN23276302 临床意义：癌症治疗中心和体检中心应考虑为适当的患者提供音乐治疗和干预作为体检期间综合临床护理的常规组成部分。
