Department of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ren Fail. 2024 Dec;46(2):2385059. doi: 10.1080/0886022X.2024.2385059. Epub 2024 Aug 13.
Systemic Immune-Inflammation Index (SII) is a novel inflammatory biomarker closely associated with the inflammatory response and chronic kidney disease. Klotho is implicated as a pathogenic factor in the progression of kidney disease, and supplementation of Klotho may delay the progression of chronic kidney disease by inhibiting the inflammatory response. Our aim is to investigate the potential relationship between SII and Klotho in adult patients in the United States and explore the differences in the populations with and without albuminuria.
We conducted a cross-sectional study recruiting adult participants with complete data on SII, Klotho, and urine albumin-to-creatinine ratio (ACR) from the National Health and Nutrition Examination Survey from 2007 to 2016. SII was calculated as platelet count × neutrophil count/lymphocyte count, with abnormal elevation defined as values exceeding 330 × 10^9/L. Albuminuria was defined as ACR >30 mg/g. Weighted multivariable regression analysis and subgroup analysis were employed to explore the independent relationship between SII and Klotho.
Our study included a total of 10,592 individuals. In all populations, non-albuminuria population, and proteinuria population with ACR ≥ 30, participants with abnormally elevated SII levels, as compared to those with SII less than 330 × 10^9/L, showed a negative correlation between elevated SII levels and increased Klotho, which persisted after adjusting for covariates.
There is a negative correlation between SII and Klotho in adult patients in the United States. This finding complements previous research but requires further analysis through large prospective studies.
全身性免疫炎症指数（SII）是一种新型炎症生物标志物，与炎症反应和慢性肾脏病密切相关。Klotho 被认为是导致肾脏病进展的致病因素，Klotho 的补充可能通过抑制炎症反应来延缓慢性肾脏病的进展。我们的目的是在美国成年患者中研究 SII 和 Klotho 之间的潜在关系，并探讨有无蛋白尿患者人群之间的差异。
我们进行了一项横断面研究，纳入了 2007 年至 2016 年期间来自美国国家健康和营养调查（NHANES）的完整 SII、Klotho 和尿白蛋白/肌酐比值（ACR）数据的成年参与者。SII 计算为血小板计数×中性粒细胞计数/淋巴细胞计数，异常升高定义为超过 330×10^9/L。蛋白尿定义为 ACR >30mg/g。采用加权多变量回归分析和亚组分析探讨 SII 与 Klotho 之间的独立关系。
我们的研究共纳入 10592 人。在所有人群、无蛋白尿人群和 ACR≥30 的蛋白尿人群中，与 SII 水平低于 330×10^9/L 的参与者相比，SII 水平升高的参与者中，SII 水平升高与 Klotho 增加之间呈负相关，调整协变量后仍保持不变。
美国成年患者中 SII 与 Klotho 之间呈负相关。这一发现补充了之前的研究，但需要通过大型前瞻性研究进行进一步分析。
