Ren Bin, Liang Jifang, Zhang Junkun, Yang Leifang, Wei Xiaocong, Guo Min, Wu Weidong, Ding Xinmin
Department of Neurosurgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan, China.
Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China.
Sci Rep. 2025 Jul 1;15(1):20468. doi: 10.1038/s41598-025-05201-y.
Traumatic Brain Injury (TBI) is a major cause of mortality and morbidity, with acute kidney injury (AKI) as a common complication. This study aimed to investigate the potential of serum Klotho protein levels as a diagnostic and prognostic marker for AKI in TBI patients.The results showed that serum Klotho level 177.3 (165.43,195.07) (pg/ml) was elevated in patients with traumatic brain injury as compared to normal group 134.8(125.6,138.9) (pg/ml) . We conducted univariate analyses of all potential factors, resulting in four variables for inclusion in the multivariate analysis. Among them, the HR value of Klotho protein was 2.076. Comparing the predictive efficacy of serum creatinine and Klotho protein, the ROC value of Klotho protein was 0.832 (95% CI: 0.709-0.898), suggesting higher predictive ability than serum creatinine. Modestly elevated serum Klotho protein levels were associated with a higher risk of AKI and a poor long-term prognosis.These findings suggested that serum Klotho protein levels may serve as an early diagnostic indicator and predictor of outcomes in TBI patients with AKI, providing insights for potential therapeutic interventions. Further research is needed to validate these findings and explore the clinical utility of targeting the Klotho pathway in TBI-associated AKI.
创伤性脑损伤（TBI）是导致死亡和发病的主要原因，急性肾损伤（AKI）是常见并发症。本研究旨在探讨血清Klotho蛋白水平作为TBI患者AKI诊断和预后标志物的潜力。结果显示，创伤性脑损伤患者血清Klotho水平为177.3（165.43,195.07）（pg/ml），高于正常组的134.8（125.6,138.9）（pg/ml）。我们对所有潜在因素进行了单因素分析，得出四个变量纳入多因素分析。其中，Klotho蛋白的HR值为2.076。比较血清肌酐和Klotho蛋白的预测效能，Klotho蛋白的ROC值为0.832（95%CI：0.709-0.898），表明其预测能力高于血清肌酐。血清Klotho蛋白水平适度升高与AKI风险增加和长期预后不良相关。这些发现表明，血清Klotho蛋白水平可能作为TBI合并AKI患者的早期诊断指标和预后预测指标，为潜在的治疗干预提供思路。需要进一步研究来验证这些发现，并探索针对TBI相关AKI中Klotho途径的临床应用价值。
