Primavera Diego, Fornaro Michele, Carrà Giuseppe, Romano Ferdinando, Aviles Gonzales Cesar Ivan, Preti Antonio, Sancassiani Federica, Cossu Giulia, Nardi Antonio Egidio, Scano Alessandra, Orrù Germano, Chessa Elisabetta, Floris Alberto, Piga Matteo, Cauli Alberto, Carta Mauro Giovanni
Department of Medical Sciences and Public Health, University of Cagliari, Italy Section of Psychiatry, Cagliari, Italy.
Department of Neuroscience, Reproductive Science and Odontostomatology Federico II University of Naples, Naples, Italy.
Clin Pract Epidemiol Ment Health. 2024 Aug 8;20:e17450179303653. doi: 10.2174/0117450179303653240705051227. eCollection 2024.
This study explores the issue of paper-and-pencil screening tests for bipolar disorder, often leading to false positives. It discusses hypotheses that connect MDQ positivity with sleep disorders, a decline in health-related quality of life, and the impact of the COVID-19 pandemic on mood disorders. The study proposes that MDQ identifies a "Dysregulation of Mood, Energy, and Social Rhythms Syndrome" (DYMERS), indicating a stress-related condition. It aims to investigate the association between MDQ positivity and systemic lupus erythematosus (SLE) in comparison to other chronic disorders.
This case-control study, conducted from April 2019 to February 2020, investigated MDQ positivity in patients with SLE. Ethical approvals were obtained, and statistical analysis was used for data assessment.
This is a case-controlled study where MDQ positivity was significantly higher in systemic lupus erythematosus cases than controls. The analysis compared gender, age, and the presence of depressive episodes between MDQ-positive and MDQ-negative cases, revealing some differences but no significant variations. Interestingly, no association with high prednisone or biologics use was observed. The frequency of MDQ positivity in systemic lupus erythematosus was compared to other chronic pathologies, revealing varying associations with each condition.
This study reveals a high rate of (MDQ) positivity in systemic lupus erythematosus (SLE), associated with the risk of bipolar disorder in SLE. Notable discrepancies in MDQ positivity risk factors between SLE and bipolar disorder are observed. The study emphasizes the ability of MDQ to identify a distinct syndrome characterized by rhythm dysregulation, posing a risk for bipolar disorder and other disorders.
本研究探讨了双相情感障碍纸笔筛查测试的问题，该测试常常导致假阳性结果。它讨论了将心境障碍问卷（MDQ）呈阳性与睡眠障碍、健康相关生活质量下降以及新冠疫情对心境障碍的影响联系起来的假设。该研究提出，MDQ识别出一种“情绪、能量和社交节律失调综合征”（DYMERS），表明这是一种与压力相关的状况。其目的是调查与其他慢性疾病相比，MDQ呈阳性与系统性红斑狼疮（SLE）之间的关联。
这项病例对照研究于2019年4月至2020年2月进行，调查了系统性红斑狼疮患者中MDQ呈阳性的情况。获得了伦理批准，并使用统计分析进行数据评估。
这是一项病例对照研究，系统性红斑狼疮病例中MDQ呈阳性的比例显著高于对照组。分析比较了MDQ阳性和阴性病例之间的性别、年龄以及抑郁发作情况，发现了一些差异，但无显著变化。有趣的是，未观察到与高剂量泼尼松或生物制剂使用的关联。将系统性红斑狼疮中MDQ呈阳性的频率与其他慢性疾病进行了比较，发现与每种疾病的关联各不相同。
本研究揭示了系统性红斑狼疮（SLE）中（MDQ）呈阳性的比例较高，这与SLE中双相情感障碍的风险相关。观察到SLE和双相情感障碍在MDQ阳性风险因素方面存在显著差异。该研究强调了MDQ识别以节律失调为特征的独特综合征的能力，这对双相情感障碍和其他疾病构成风险。
