Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia (S.S.S., P.J.F., M.J.Y., J.Y.).
Department of Endocrinology, Monash Health, Clayton, Victoria, Australia (S.S.S., P.J.F., J.Y.).
Hypertension. 2024 Oct;81(10):2038-2048. doi: 10.1161/HYPERTENSIONAHA.124.23385. Epub 2024 Aug 13.
Low-renin hypertension is common and affects 1 in 4 people with hypertension. Understanding the different causes and management of low-renin hypertension is becoming increasingly relevant as renin measurements are more widely ordered in clinical practice. Importantly, many people with low-renin hypertension do not fit traditional definitions of known causes, and the approach to management of these people is not unclear. This review provides an overview of our evolving understanding of the causes of low-renin hypertension, the expanding spectrums of pathophysiology, key differentiating characteristics, distinct management strategies, and highlights our knowledge gaps. It is important to distinguish the underlying pathophysiology of an individual with low-renin hypertension to individualize treatment.
低肾素型高血压较为常见，影响着每 4 名高血压患者中的 1 名。随着肾素检测在临床实践中更为广泛地应用，了解低肾素型高血压的不同病因和管理方法变得越来越重要。重要的是，许多低肾素型高血压患者不符合已知病因的传统定义，而这些患者的管理方法尚不清楚。这篇综述概述了我们对低肾素型高血压病因的不断认识、不断扩展的病理生理学范围、关键鉴别特征、不同的管理策略，并突出了我们的知识空白。区分低肾素型高血压患者的潜在病理生理学特征以实现个体化治疗非常重要。
