从毛叶天仙藤中分离得到的三种未描述的呋喃二萜类化合物可抑制一氧化氮的产生。
Three Undescribed Furanoditerpenoids from the Tinospora crispa that Inhibit NO Production.
作者信息
Van Quoc Nguyen, Huu Tai Bui, Hai Yen Pham, Huy Hoang Nguyen, Thuy Hang Dan Thi, Thanh Huong Phan Thi, Anh Bang Ngo, Thi Dung Duong, Thi Trang Do, Giang Le Duc, Van Kiem Phan
机构信息
School of Chemistry, Biology and Environment, Vinh University, 182 Le Duan, Ben Thuy, Vinh City, Nghe An, 461010, Vietnam.
Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
出版信息
Chem Biodivers. 2024 Dec;21(12):e202401679. doi: 10.1002/cbdv.202401679. Epub 2024 Oct 11.
Phytochemical study on the methanol extract of the stems of Tinospora crispa (L.) Hook.f. & Thomson led to the isolation of thirteen compounds including three undescribed cis-clerodane-type furanoditerpenoids (1-3) and ten known ones (4-13). Their chemical structures were determined by IR, HR-ESI-MS, 1D-, and 2D-NMR spectra. Compounds 2-4, 6 and 8 inhibited moderately NO production in LPS activated RAW 264.7 cells with the IC values of 83.5, 57.6, 75.3, 78.1, and 74.7 μM, respectively.
对毛青牛胆（Tinospora crispa (L.) Hook.f. & Thomson）茎的甲醇提取物进行植物化学研究，从中分离出13种化合物，包括3种未描述的顺式克罗烷型呋喃二萜（1 - 3）和10种已知化合物（4 - 13）。通过红外光谱（IR）、高分辨电喷雾电离质谱（HR - ESI - MS）、一维和二维核磁共振谱（1D - 和2D - NMR）确定了它们的化学结构。化合物2 - 4、6和8对脂多糖激活的RAW 264.7细胞中一氧化氮（NO）的产生有中度抑制作用，其半数抑制浓度（IC）值分别为83.5、57.6、75.3、78.1和74.7 μM。
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