H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.
J Nat Prod. 2010 Apr 23;73(4):541-7. doi: 10.1021/np900551u.
Phytochemical and cytotoxicity investigations on organic solvent extracts of the aerial parts of Tinospora crispa have led to the isolation of 15 cis-clerodane-type furanoditerpenoids. Of these, nine compounds (1-9) were found to be new. Spectroscopic assignments of a previously reported compound, borapetoside A (13), were revised on the basis of HMQC and HMBC correlations. No discernible activity was observed when compounds 10-13 were subjected to evaluation in cytotoxicity assays against human prostate cancer (PC-3) and the normal mouse fibroblast (3T3) cell lines.
对鸡血藤地上部分的有机溶剂提取物进行的植物化学和细胞毒性研究，导致分离出 15 种顺式-克氏型呋喃二萜。其中，有 9 种化合物（1-9）为新化合物。根据 HMQC 和 HMBC 相关谱，对先前报道的化合物硼柏苷 A（13）的光谱分配进行了修订。当化合物 10-13 进行细胞毒性测定，评估对人前列腺癌（PC-3）和正常小鼠成纤维细胞（3T3）细胞系的活性时，没有观察到明显的活性。
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