从蒺藜果实中分离得到的五种具有一氧化氮生成抑制活性的新呋甾烷醇糖苷。
Five New Furostanol Glycosides from the Fruits of Tribulus terrestris with NO Production Inhibitory Activity.
作者信息
Kiem Phan Van, Quoc Nguyen Van, Tai Bui Huu, Yen Pham Hai, Huy Hoang Nguyen, Thi Thuy Hang Dan, Huong Phan Thi Thanh, Anh Bang Ngo, Dung Duong Thi, Trang Do Thi, Giang Le Duc
机构信息
Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
School of Chemistry, Biology and Environment, Vinh University, 182 Le Duan, Ben Thuy, Vinh City, Nghe An, 461010, Vietnam.
出版信息
Chem Biodivers. 2024 Sep;21(9):e202401273. doi: 10.1002/cbdv.202401273. Epub 2024 Jul 16.
Eight furostanol glycosides including five undescribed compounds, named tribufurostanosides A-E (1-5), and three known ones (6-8) were isolated from the fruits of Tribulus terrestris L. Their chemical structures were determined by the IR, HR-ESI-MS, 1D-, and 2D-NMR spectra. Furostanols 1-8 significantly inhibited nitric oxide production in LPS activated RAW 264.7 cells with IC values ranging from 14.2 to 64.7 μM, compared to that of the positive control compound, dexamethazone (IC 13.6 μM).
从刺蒺藜果实中分离出8种呋甾烷醇苷，其中包括5种未描述的化合物，命名为刺蒺藜呋甾烷苷A - E（1 - 5），以及3种已知化合物（6 - 8）。通过红外光谱（IR）、高分辨电喷雾电离质谱（HR - ESI - MS）、一维核磁共振（1D - NMR）和二维核磁共振（2D - NMR）光谱确定了它们的化学结构。与阳性对照化合物地塞米松（IC 13.6 μM）相比，呋甾烷醇1 - 8显著抑制脂多糖激活的RAW 264.7细胞中一氧化氮的产生，IC值范围为14.2至64.7 μM。
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