Division of Genetics, Department of Biology, Nikolaus-Fiebiger-Zentrum, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Eur J Immunol. 2024 Nov;54(11):e2451076. doi: 10.1002/eji.202451076. Epub 2024 Aug 13.
The intestinal epithelium harbours a unique lymphocyte population, the intraepithelial lymphocytes (IELs). A large fraction of IELs is represented by γδ T cells. Their role in epithelial homeostasis and immune response is well documented, but a conclusive view of their developmental pathway is still missing. In this review, we discuss the existing literature as well as recent advances regarding the tissue adaptation of γδ IELs, both for the characteristic cytotoxic subset and the newly described noncytotoxic subset. We particularly highlight the environmental cues and the transcriptional regulation that equip γδ T cells with their IEL phenotype.
肠上皮含有独特的淋巴细胞群体，即上皮内淋巴细胞（IELs）。IELs 的很大一部分由 γδ T 细胞组成。它们在上皮稳态和免疫反应中的作用已有充分的文献记载，但对于其发育途径仍缺乏明确的认识。在这篇综述中，我们讨论了关于 γδ IEL 组织适应性的现有文献和最新进展，包括特征性的细胞毒性亚群和新描述的非细胞毒性亚群。我们特别强调了使 γδ T 细胞获得 IEL 表型的环境线索和转录调控。
