Ermawan Romi, Pintaningrum Yusra, Indrayana Yanna
Faculty of Medicine, Mataram University, FK UNRAM, Jl. Pendidikan, No. 37, Mataram, NTB, Indonesia.
Egypt Heart J. 2024 Aug 13;76(1):103. doi: 10.1186/s43044-024-00536-9.
A new challenge in coronary artery disease treatment has emerged, where specific populations exhibit ischemic symptoms without any obstruction in the epicardial coronary artery. Instead, they exhibit slow coronary contrast flow, referred to as coronary slow flow (CSF). This study aims to identify several predictors of CSF.
This case-control study was conducted at the Regional General Hospital of West Nusa Tenggara Province in Indonesia from December 2016 to February 2024. The study involved sixty subjects, with 30 in each group of CSF and normal epicardial coronary artery angiogram (NECA). CSF is enforced by the TIMI frame count (TFC) greater than 27 frames. Among all the predictors studied, coronary artery diameter (p < 0.001) and random blood sugar (p = 0.049) were found to affect the CSF significantly. In the multivariate analysis, coronary artery diameter remained a significant predictor (adjusted OR 10.08, 95% CI 2.64-38.50, p < 0.001), with an optimal cut-off point of more than 3.56 mm, a sensitivity of 76.7%, and a specificity of 70.7% (AUC = 0.787, p < 0.001).
The coronary artery diameter strongly predicts CSF in patients undergoing coronary angiography.
冠状动脉疾病治疗中出现了一个新挑战，即特定人群在冠状动脉造影时显示心外膜冠状动脉无阻塞，但却有缺血症状。相反，他们表现为冠状动脉造影剂缓慢充盈，称为冠状动脉慢血流（CSF）。本研究旨在确定CSF的几个预测因素。
本病例对照研究于2016年12月至2024年2月在印度尼西亚西努沙登加拉省地区总医院进行。该研究纳入了60名受试者，CSF组和正常心外膜冠状动脉造影（NECA）组各30名。通过TIMI帧数（TFC）大于27帧来确定CSF。在所有研究的预测因素中，发现冠状动脉直径（p < 0.001）和随机血糖（p = 0.049）对CSF有显著影响。在多变量分析中，冠状动脉直径仍然是一个显著的预测因素（调整后的OR为10.08，95%CI为2.64 - 38.50，p < 0.001），最佳截断点为大于3.56毫米，灵敏度为76.7%，特异性为70.7%（AUC = 0.787，p < 0.001）。
冠状动脉直径是冠状动脉造影患者CSF的强预测因素。
