Li Helin, Zhang Wenjing, Meng Qiu, Shuai Qi
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014, China.
College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014, China.
Invest New Drugs. 2024 Oct;42(5):590-600. doi: 10.1007/s10637-024-01460-0. Epub 2024 Aug 13.
The therapeutic effects of many pharmacotherapies have been explored, but disadvantages such as low drug specificity, drug resistance and side effects makes their effective delivery to target sites a great challenge. Consequently, a distinctive prodrug-based technology have emerged as an effective treatments because of their distinctive advantages, such as high drug loading capacity, precise targeting, reduced side effects and spatial and temporal controllability. In particular, the use of gamma/X-ray-mediated strategies in radiotherapy is a new strategy that could enable the precise drug release from implanted devices. This review presents readers with the current state of prodrug therapy and reports the design protocols of rational and effective prodrugs for clinical use.
许多药物疗法的治疗效果已得到探索，但诸如药物特异性低、耐药性和副作用等缺点使得将其有效递送至靶位点成为一项巨大挑战。因此，一种独特的基于前药的技术因其独特优势，如高载药量、精准靶向、副作用减少以及时空可控性等，已成为一种有效的治疗方法。特别是，在放射治疗中使用γ/ X射线介导的策略是一种新策略，它能够使药物从植入装置中精确释放。本综述向读者介绍了前药疗法的现状，并报告了用于临床的合理且有效的前药的设计方案。
