Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, U.S.A.
Department of Ophthalmology and Visual Sciences, W. K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, U.S.A.
Ophthalmic Plast Reconstr Surg. 2024;40(6):e223-e225. doi: 10.1097/IOP.0000000000002740. Epub 2024 Aug 13.
Squamous cell carcinoma of the orbit is uncommon as there is no squamous epithelium in the orbit. Thus, mechanistically squamous cell carcinoma of the orbit most commonly arises from a cutaneous lesion. Although orbital epidermoid cysts are thought to have very low malignant potential, these lesions possess squamous epithelium and theoretically can undergo malignant transformation. Here, the authors present the case of a 63-year-old woman who presented with a 3-month history of diplopia and forehead tenderness with an orbital extraconal lesion on MRI consistent with a ruptured epidermoid cyst. Six months following resection, she suddenly experienced new-onset left upper eyelid ptosis, recurrent diplopia, and left orbital pain. MRI revealed a recurrence of the left orbital mass. Left anterior orbitotomy and biopsy revealed cystic squamous cell carcinoma. This case appears to demonstrate a very rare malignant transformation of an epidermoid cyst to cystic squamous cell carcinoma.
眼眶鳞状细胞癌并不常见，因为眼眶内没有鳞状上皮。因此，从机制上讲，眼眶鳞状细胞癌最常起源于皮肤病变。尽管眶内表皮样囊肿的恶性潜能被认为非常低，但这些病变具有鳞状上皮，理论上可以发生恶性转化。在此，作者报告了一例 63 岁女性患者，其病史为 3 个月的复视和额部压痛，MRI 显示眶外病变符合破裂的表皮样囊肿。切除后 6 个月，她突然出现左眼上睑下垂、复视和左眼眶疼痛新发作。MRI 显示左眼眶肿块复发。左前眶切开术和活检显示囊性鳞状细胞癌。本例似乎表明表皮样囊肿非常罕见地恶变为囊性鳞状细胞癌。
