Webber D E, Morrissey S M
Can J Physiol Pharmacol. 1979 Nov;57(11):1283-8. doi: 10.1139/y79-193.
The level of hypoglycaemia required to elicit gastric secretion of acid and pepsin was studied in urethane-anaesthetized rats. Hypoglycaemia was induced by intravenous injection of insulin or by electrical stimulation of the posterior hypothalamus. In each case the blood glucose values below which gastric secretion was stimulated were significantly higher for pepsin than for acid secretion. This consistently resulted in the onset of pepsin secretion in advance of the onset of acid secretion. These observations suggest that the production of the different components of the gastric juice was under the influence of either separate hypothalamic glucoreceptors, or a single set of glucoreceptors able to respond selectively to different blood glucose levels.
在氨基甲酸乙酯麻醉的大鼠中，研究了引发胃酸和胃蛋白酶分泌所需的低血糖水平。通过静脉注射胰岛素或电刺激下丘脑后部诱导低血糖。在每种情况下，刺激胃分泌的血糖值，胃蛋白酶分泌的显著高于胃酸分泌。这始终导致胃蛋白酶分泌先于胃酸分泌开始。这些观察结果表明，胃液不同成分的产生受下丘脑不同葡萄糖感受器或一组能够选择性响应不同血糖水平的单一葡萄糖感受器的影响。
