内脏切除术和迷走神经切断术对胃蛋白酶原对胃内酸反应的影响。
Effect of splanchnectomy and vagotomy on the pepsinogen response to intragastric acid.
作者信息
Webber D E, Morrissey S M
出版信息
Experientia. 1980 Aug 15;36(8):989-90. doi: 10.1007/BF01953838.
PMID:7439339
Abstract
Perfusion of the stomach in the anaesthetized rat with saline acidified to pH 2.5 with hydrochloric acid induced a small but significant release of pepsinogen into the perfusate. This stimulus to secretion was unaffected by splanchnectomy but was abolished by vagotomy. It is concluded that a modest degree acid secretion in the rat may stimulate pepsinogen secretion by a vagal pathway.
摘要
用盐酸将麻醉大鼠胃内灌注液酸化至pH 2.5，可使少量但显著量的胃蛋白酶原释放到灌流液中。这种分泌刺激不受内脏神经切除术的影响，但迷走神经切断术可消除该刺激。由此得出结论，大鼠适度的胃酸分泌可能通过迷走神经途径刺激胃蛋白酶原分泌。
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