Kelton J G, Blajchman M A
Can Med Assoc J. 1979 Nov 17;121(10):1353-8.
Platelets play a pivotal role in hemostasis by forming the initial hemostatic plug and augmenting the formation of the more permanent fibrin thrombus. Thrombocytopenia may lead to bleeding, which can be treated with therapeutic platelet transfusions or prevented with prophylactic transfusions. While many advances have been made in platelet transfusion technology, problems remain. These include the short storage life of liquid-stored platelets and the frequent development of alloantibodies (the refractory state) in patients receiving a number of transfusions. Significant progress, however, is being made in both areas.
血小板通过形成初始止血栓并促进更持久的纤维蛋白血栓形成，在止血过程中发挥关键作用。血小板减少症可能导致出血，可通过治疗性血小板输注进行治疗，或通过预防性输注加以预防。尽管血小板输注技术已取得诸多进展，但问题依然存在。这些问题包括液态储存血小板的储存寿命较短，以及接受多次输血的患者中频繁出现同种抗体（难治状态）。然而，这两个领域都正在取得重大进展。
