高密度脂蛋白、逆向胆固醇转运与动脉粥样硬化：是揭示复杂性还是徒增困惑？ - Suppr

HDL, reverse cholesterol transport, and atherosclerosis: Unravelling the complexity or adding to the confusion?

作者信息

Parini Paolo

机构信息

Cardio Metabolic Unit, Dept of Medicine and Dept of Laboratory Medicine, Karolinska Institutet; and Medical Unit Endocrinology, Theme Inflammation and Ageing, Karolinska University Hospital, Stockholm, Sweden.

出版信息

Atherosclerosis. 2024 Oct;397:118562. doi: 10.1016/j.atherosclerosis.2024.118562. Epub 2024 Aug 8.

DOI:10.1016/j.atherosclerosis.2024.118562

PMID:39137620

Abstract

摘要

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HDL, reverse cholesterol transport, and atherosclerosis: Unravelling the complexity or adding to the confusion?高密度脂蛋白、逆向胆固醇转运与动脉粥样硬化：是揭示复杂性还是徒增困惑？

Atherosclerosis. 2024 Oct;397:118562. doi: 10.1016/j.atherosclerosis.2024.118562. Epub 2024 Aug 8.

Probucol-Oxidized Products, Spiroquinone and Diphenoquinone, Promote Reverse Cholesterol Transport in Mice.普罗布考氧化产物、螺醌和二苯醌促进小鼠体内的胆固醇逆向转运。

Arterioscler Thromb Vasc Biol. 2016 Apr;36(4):591-7. doi: 10.1161/ATVBAHA.115.306376. Epub 2016 Feb 4.

Liver ABCA1 deletion in LDLrKO mice does not impair macrophage reverse cholesterol transport or exacerbate atherogenesis.ABCA1 基因在肝脏中的缺失并不会损害 LDLrKO 小鼠的巨噬细胞逆向胆固醇转运，也不会加剧动脉粥样硬化的形成。

Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2288-96. doi: 10.1161/ATVBAHA.112.301110. Epub 2013 Jun 27.

Rosuvastatin activates ATP-binding cassette transporter A1-dependent efflux ex vivo and promotes reverse cholesterol transport in macrophage cells in mice fed a high-fat diet.瑞舒伐他汀在体外激活ATP结合盒转运体A1依赖性流出，并促进高脂饮食喂养小鼠巨噬细胞中的胆固醇逆向转运。

Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2246-53. doi: 10.1161/ATVBAHA.114.303715. Epub 2014 Aug 7.

Effects of native and myeloperoxidase-modified apolipoprotein a-I on reverse cholesterol transport and atherosclerosis in mice.天然载脂蛋白 A-I 和髓过氧化物酶修饰载脂蛋白 A-I 对小鼠胆固醇逆向转运和动脉粥样硬化的影响。

Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):779-89. doi: 10.1161/ATVBAHA.113.303044. Epub 2014 Jan 9.

LXR driven induction of HDL-cholesterol is independent of intestinal cholesterol absorption and ABCA1 protein expression.肝脏X受体驱动的高密度脂蛋白胆固醇诱导与肠道胆固醇吸收及ABCA1蛋白表达无关。

Lipids. 2014 Jan;49(1):71-83. doi: 10.1007/s11745-013-3853-8. Epub 2013 Oct 27.

Chitosan Oligosaccharides Attenuate Atherosclerosis and Decrease Non-HDL in ApoE-/- Mice.壳寡糖减轻载脂蛋白E基因敲除小鼠的动脉粥样硬化并降低非高密度脂蛋白水平

J Atheroscler Thromb. 2015;22(9):926-41. doi: 10.5551/jat.22939. Epub 2015 Apr 3.

Pharmacologic suppression of hepatic ATP-binding cassette transporter 1 activity in mice reduces high-density lipoprotein cholesterol levels but promotes reverse cholesterol transport.在小鼠中抑制肝 ATP 结合盒转运蛋白 1 活性可降低高密度脂蛋白胆固醇水平，但促进胆固醇逆转运。

Circulation. 2011 Sep 20;124(12):1382-90. doi: 10.1161/CIRCULATIONAHA.110.009704. Epub 2011 Aug 22.

Vitamin D Protects Against Atherosclerosis via Regulation of Cholesterol Efflux and Macrophage Polarization in Hypercholesterolemic Swine.维生素 D 通过调节高胆固醇血症猪的胆固醇外排和巨噬细胞极化来预防动脉粥样硬化。

Arterioscler Thromb Vasc Biol. 2015 Nov;35(11):2432-42. doi: 10.1161/ATVBAHA.115.306132. Epub 2015 Sep 17.

HDL, cholesterol efflux, and ABCA1: Free from good and evil dualism.高密度脂蛋白胆固醇外排与 ABCA1：摆脱善恶二元论。

J Pharmacol Sci. 2022 Oct;150(2):81-89. doi: 10.1016/j.jphs.2022.07.004. Epub 2022 Aug 6.

引用本文的文献

Comprehensive Insights into the Cholesterol-Mediated Modulation of Membrane Function Through Molecular Dynamics Simulations.通过分子动力学模拟对胆固醇介导的膜功能调节的全面洞察

Membranes (Basel). 2025 Jun 8;15(6):173. doi: 10.3390/membranes15060173.

Comprehensive Insights into the Cholesterol-Mediated Modulation of Membrane Function through Molecular Dynamics Simulations.通过分子动力学模拟对胆固醇介导的膜功能调节的全面洞察。

ArXiv. 2025 Apr 7:arXiv:2504.05564v1.

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HDL, reverse cholesterol transport, and atherosclerosis: Unravelling the complexity or adding to the confusion?

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