类风湿关节炎的长期甲氨蝶呤治疗：综述
Longterm methotrexate therapy in rheumatoid arthritis: a review.
作者信息
Kremer J M
出版信息
J Rheumatol Suppl. 1985 Dec;12 Suppl 12:25-8.
PMID:3913773
Abstract
A review of the literature on the longterm use of methotrexate in patients with rheumatoid arthritis (RA) showed that many questions on protocol remain unanswered. Although rheumatologists have adopted certain guidelines previously followed by dermatologists for psoriasis patients, rheumatology literature offers no set of rules for using the drug in treating patients with RA. The use of liver function tests and liver biopsy specimens to predict and assess hepatotoxicity associated with methotrexate use is also discussed.
摘要
一项关于甲氨蝶呤在类风湿关节炎（RA）患者中长期使用的文献综述表明，许多关于用药方案的问题仍未得到解答。尽管风湿病学家采用了皮肤科医生先前针对银屑病患者的某些指导原则，但风湿病学文献中并未提供在治疗RA患者时使用该药物的一套规则。文中还讨论了使用肝功能测试和肝活检标本预测和评估与甲氨蝶呤使用相关的肝毒性。
相似文献
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Longterm methotrexate therapy in rheumatoid arthritis: a review.类风湿关节炎的长期甲氨蝶呤治疗：综述
J Rheumatol Suppl. 1985 Dec;12 Suppl 12:25-8.
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Short term efficacy of methotrexate in the treatment of rheumatoid arthritis.甲氨蝶呤治疗类风湿关节炎的短期疗效
J Rheumatol Suppl. 1985 Dec;12 Suppl 12:21-4.
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[Methotrexate, liver and rheumatoid arthritis in tropical areas].[甲氨蝶呤、肝脏与热带地区的类风湿关节炎]
Sante. 2001 Jul-Sep;11(3):195-200.
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Hepatotoxicity of methotrexate in the treatment of psoriasis.甲氨蝶呤治疗银屑病时的肝毒性。
Practitioner. 1973 Sep;211(263):324-8.
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Hepatotoxicity associated with low-dose, long-term methotrexate treatment of rheumatoid arthritis.低剂量、长期使用甲氨蝶呤治疗类风湿关节炎相关的肝毒性。
Scand J Rheumatol. 1987;16(4):229-34. doi: 10.3109/03009748709102922.
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Slow-acting anti-rheumatic drug therapy for rheumatoid arthritis.类风湿关节炎的慢作用抗风湿药物治疗
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Low incidence of hepatotoxicity associated with long-term, low-dose oral methotrexate in treatment of refractory psoriasis, psoriatic arthritis, and rheumatoid arthritis. An acceptable risk/benefit ratio.长期低剂量口服甲氨蝶呤治疗难治性银屑病、银屑病关节炎和类风湿关节炎时肝毒性发生率低。风险/效益比可接受。
Dig Dis Sci. 1985 Feb;30(2):104-9. doi: 10.1007/BF01308193.
引用本文的文献
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[Conventional basis therapy of rheumatoid arthritis. Effects within and outside cells].[类风湿关节炎的传统基础治疗。细胞内外的作用]
Z Rheumatol. 2012 Aug;71(6):468-72. doi: 10.1007/s00393-011-0878-3.
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Methotrexate therapy in rheumatoid arthritis. A two year prospective follow-up.类风湿关节炎的甲氨蝶呤治疗。一项为期两年的前瞻性随访。
Clin Rheumatol. 1990 Sep;9(3):333-41. doi: 10.1007/BF02114393.
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