MacLeod S M, Hamet P, Kaplan H, Larochelle P, Nadeau J, Ogilvie R I, Rangno R E, Ruedy J, Sellers E M, Ti T Y
Can Med Assoc J. 1979 Sep 22;121(6):737-40.
The therapeutic efficacy of propranolol in four and two daily doses was compared in 63 treated hypertensive patients in a multicentre trial. After 3 months of a stable diastolic blood pressure while receiving propranolol four times a day the patients were switched to a twice-a-day regimen, the drug being given at 8 am and 8 pm, with the same total daily dose, for 3 more months. Blood pressures and heart rates were measured at 8 am, 12 noon, 4 pm and 8 pm at 4-week intervals. There were no significant changes in mean blood pressure after the change to the twice-a-day regimen, although some patients reported new side effects. Compliance appeared to be unaffected.
在一项多中心试验中，对63例接受治疗的高血压患者比较了每日服用4次和2次普萘洛尔的治疗效果。在每天服用4次普萘洛尔且舒张压稳定3个月后，患者改为每日2次给药方案，即上午8点和晚上8点服用相同总日剂量的药物，持续3个月。每隔4周于上午8点、中午12点、下午4点和晚上8点测量血压和心率。改为每日2次给药方案后，平均血压无显著变化，尽管一些患者报告出现了新的副作用。依从性似乎未受影响。
