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1
The effect on blood pressure of beta-adrenoceptor blocking drugs administered once daily and their duration of action when therapy is ceased.每日服用一次的β-肾上腺素能受体阻断药物对血压的影响及其停药后的作用持续时间。
Br J Clin Pharmacol. 1976 Oct;3(5):857-61. doi: 10.1111/j.1365-2125.1976.tb00638.x.
2
Beta-adrenergic receptor blocking drugs, hypertension and plasma renin.β-肾上腺素能受体阻断药物、高血压与血浆肾素
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3
The effect on blood pressure of beta-adrenoreceptor-blocking drugs given once daily.每日服用一次β-肾上腺素能受体阻滞剂对血压的影响。
Clin Sci Mol Med Suppl. 1976 Dec;3:527s-528s. doi: 10.1042/cs051527s.
4
Beta adrenoreceptor-blocking drugs once daily in essential hypertension: a comparison of propranolol, pindolol and atenolol.β肾上腺素能受体阻滞剂治疗原发性高血压每日一次：普萘洛尔、吲哚洛尔和阿替洛尔的比较。
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5
Hemodynamic and hormonal adaptations to beta-adrenoceptor blockade. A 24-hour study of acebutolol, atenolol, pindolol, and propranolol in hypertensive patients.β-肾上腺素能受体阻滞剂的血流动力学和激素适应性。对高血压患者进行的醋丁洛尔、阿替洛尔、吲哚洛尔和普萘洛尔的24小时研究。
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6
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7
Ambulatory blood pressure during once-daily randomised double-blind administration of atenolol, metoprolol, pindolol, and slow-release propranolol.阿替洛尔、美托洛尔、吲哚洛尔和缓释普萘洛尔每日一次随机双盲给药期间的动态血压
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8
Comparison of the onset of the antihypertensive action of pindolol and propranolol. A 24 h haemodynamic study.吲哚洛尔与普萘洛尔降压作用起效时间的比较。一项24小时血流动力学研究。
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Once-a-day pindolol in hypertension.高血压患者每日一次服用吲哚洛尔。
Clin Pharmacol Ther. 1977 May;21(5):588-92. doi: 10.1002/cpt1977215588.
10
Different antihypertensive effect of beta-blocking drugs in low and normal-high renin hypertension.β受体阻滞剂在低肾素型和正常高肾素型高血压中的不同降压作用。
Am J Med. 1976 May 31;60(6):891-6. doi: 10.1016/0002-9343(76)90910-4.

引用本文的文献

1
Nontraditional problems of antihypertensive management.抗高血压管理的非传统问题。
West J Med. 1979 Sep;131(3):179-92.
2
Comparison of the efficacy and pharmacokinetics of conventional propranolol and a long acting preparation of propranolol.常规普萘洛尔与长效普萘洛尔制剂的疗效及药代动力学比较。
Br J Clin Pharmacol. 1980 Jan;9(1):33-40. doi: 10.1111/j.1365-2125.1980.tb04793.x.
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Does the frequency of daily dosage influence compliance with digoxin therapy?每日给药剂量的频率会影响地高辛治疗的依从性吗？
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4
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5
Ambulatory blood pressure during once-daily randomised double-blind administration of atenolol, metoprolol, pindolol, and slow-release propranolol.阿替洛尔、美托洛尔、吲哚洛尔和缓释普萘洛尔每日一次随机双盲给药期间的动态血压
Br Med J (Clin Res Ed). 1982 Nov 13;285(6352):1387-92. doi: 10.1136/bmj.285.6352.1387.
6
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Br J Clin Pharmacol. 1980 Feb;9(2):209-12. doi: 10.1111/j.1365-2125.1980.tb05835.x.
7
A study of nadolol to determine its effect on ambulatory blood pressure over 24 hours, and during exercise testing.一项关于纳多洛尔的研究，以确定其对24小时动态血压以及运动测试期间血压的影响。
Br J Clin Pharmacol. 1982 Jul;14(1):83-8. doi: 10.1111/j.1365-2125.1982.tb04938.x.
8
Comparison between atenolol and nadolol in essential hypertension at rest and on exercise.阿替洛尔与纳多洛尔在原发性高血压静息及运动状态下的比较。
Br J Clin Pharmacol. 1982 Jun;13(6):841-6. doi: 10.1111/j.1365-2125.1982.tb01876.x.
9
Propranolol and beta-adrenergic receptor blocking drugs in the treatment of hypertension.普萘洛尔及β-肾上腺素能受体阻断药治疗高血压
Br J Clin Pharmacol. 1982 Jan;13(1):51-60. doi: 10.1111/j.1365-2125.1982.tb01336.x.
10
Comparative study of atenolol, metoprolol, metoprolol durules, and slow-release oxprenolol in essential hypertension.阿替洛尔、美托洛尔、美托洛尔缓释片和氧烯洛尔缓释片治疗原发性高血压的比较研究
Br Heart J. 1981 Nov;46(5):498-502. doi: 10.1136/hrt.46.5.498.

本文引用的文献

1
Treatment of hypertension with propranolol.用普萘洛尔治疗高血压。
Br Med J. 1969 Jan 4;1(5635):7-16. doi: 10.1136/bmj.1.5635.7.
2
Propranolol inhibition of renin secretion. A specific approach to diagnosis and treatment of renin-dependent hypertensive diseases.普萘洛尔对肾素分泌的抑制作用。一种诊断和治疗肾素依赖性高血压疾病的特定方法。
N Engl J Med. 1972 Dec 14;287(24):1209-14. doi: 10.1056/NEJM197212142872401.
3
Hypertension--1974.
Arch Intern Med. 1974 Jun;133(6):911-3. doi: 10.1001/archinte.133.6.911.
4
Blood pressure crisis following withdrawal of clonidine (Catapres, Catapresan), with special reference to arterial and urinary catecholamine levels, and suggestions for acute management.
Am Heart J. 1973 May;85(5):605-10. doi: 10.1016/0002-8703(73)90165-8.
5
Beta-adrenergic receptor blocking drugs, hypertension and plasma renin.β-肾上腺素能受体阻断药物、高血压与血浆肾素
Br J Clin Pharmacol. 1975 Apr;2(2):159-64. doi: 10.1111/j.1365-2125.1975.tb01571.x.

每日服用一次的β-肾上腺素能受体阻断药物对血压的影响及其停药后的作用持续时间。

The effect on blood pressure of beta-adrenoceptor blocking drugs administered once daily and their duration of action when therapy is ceased.

作者信息

Wilson M, Morgan G, Morgan T

出版信息

Br J Clin Pharmacol. 1976 Oct;3(5):857-61. doi: 10.1111/j.1365-2125.1976.tb00638.x.

DOI:10.1111/j.1365-2125.1976.tb00638.x
PMID:788758
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1428952/
Abstract

The control of blood pressure achieved was similar whether pindolol or propranolol was given once or three times daily. When the drugs were ceased the antihypertensive effect lasted for longer than 24 h. There was no rebound hypertension. The full effect of the drug on blood pressure was seen within 24 h of its recommencement. Changes in blood pressure, pulse rate, and plasma renin activity occurred but these were not considered to be causally related. The response of plasma renin activity to posture was ablated when the patients were receiving beta-adrenoceptor blocking drugs.

摘要

无论吲哚洛尔或普萘洛尔每日给药一次还是三次，所实现的血压控制效果相似。当停药时，降压作用持续超过24小时。未出现反跳性高血压。再次开始用药后24小时内可见药物对血压的充分作用。血压、脉搏率和血浆肾素活性发生了变化，但这些变化不被认为存在因果关系。当患者接受β-肾上腺素能受体阻断药物时，血浆肾素活性对体位的反应被消除。