每日服用一次的β-肾上腺素能受体阻断药物对血压的影响及其停药后的作用持续时间。
The effect on blood pressure of beta-adrenoceptor blocking drugs administered once daily and their duration of action when therapy is ceased.
作者信息
Wilson M, Morgan G, Morgan T
出版信息
Br J Clin Pharmacol. 1976 Oct;3(5):857-61. doi: 10.1111/j.1365-2125.1976.tb00638.x.
Abstract
The control of blood pressure achieved was similar whether pindolol or propranolol was given once or three times daily. When the drugs were ceased the antihypertensive effect lasted for longer than 24 h. There was no rebound hypertension. The full effect of the drug on blood pressure was seen within 24 h of its recommencement. Changes in blood pressure, pulse rate, and plasma renin activity occurred but these were not considered to be causally related. The response of plasma renin activity to posture was ablated when the patients were receiving beta-adrenoceptor blocking drugs.
摘要
无论吲哚洛尔或普萘洛尔每日给药一次还是三次，所实现的血压控制效果相似。当停药时，降压作用持续超过24小时。未出现反跳性高血压。再次开始用药后24小时内可见药物对血压的充分作用。血压、脉搏率和血浆肾素活性发生了变化，但这些变化不被认为存在因果关系。当患者接受β-肾上腺素能受体阻断药物时，血浆肾素活性对体位的反应被消除。
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