The PubPeer conundrum: Administrative challenges in research misconduct proceedings.

The founders of PubPeer envisioned their website as an online form of a "journal club" that would facilitate post-publication peer review. Recently, PubPeer comments have led to a significant number of research misconduct proceedings - a development that could not have been anticipated when the current federal research misconduct regulations were developed two decades ago. Yet the number, frequency, and velocity of PubPeer comments identifying data integrity concerns, and institutional and government practices that treat all such comments as potential research misconduct allegations, have overwhelmed institutions and threaten to divert attention and resources away from other research integrity initiatives. Recent, high profile research misconduct cases accentuate the increasing public interest in research integrity and make it inevitable that the use of platforms such as PubPeer to challenge research findings will intensify. This article examines the origins of PubPeer and its central role in the modern era of online-based scouring of scientific publications for potential problems and outlines the challenges that institutions must manage in addressing issues identified on PubPeer. In conclusion, we discuss some potential enhancements to the investigatory process specified under federal regulations that could, if implemented, allow institutions to manage some of these challenges more efficiently.