Kang Dong-Woo, Wang Sheng-Min, Kim Tae-Yeong, Kim Donghyeon, Na Hae-Ran, Kim Nak-Young, Lee Chang-Uk, Lim Hyun-Kook
Department of Psychiatry, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Department of Psychiatry, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 07345, Korea.
Brain Sci. 2021 Jun 10;11(6):772. doi: 10.3390/brainsci11060772.
Anodal transcranial direct current stimulation (anodal-tDCS) is known to improve cognition and normalize abnormal network configuration during resting-state functional magnetic resonance imaging (fMRI) in patients with mild cognitive impairment (MCI). We aimed to evaluate the impact of sequential anodal-tDCS on cognitive functions, functional segregation, and integration parameters in patients with MCI, according to high-risk factors for Alzheimer's disease (AD): amyloid-beta (Aβ) deposition and ε4-allele status. In 32 patients with MCI ([ F] flutemetamol-: = 10, [ F] flutemetamol+: = 22; ε4-: = 13, ε4+: = 19), we delivered anodal-tDCS (2 mA/day, five times/week, for 2 weeks) over the left dorsolateral prefrontal cortex and assessed the neuropsychological test battery and resting-state fMRI measurements before and after 2 weeks stimulation. We observed a non-significant impact of an anodal-tDCS on changes in neuropsychological battery scores between MCI patients with and without high-risk factors of AD, Aβ retention and ε4-allele. However, there was a significant difference in brain functional segregation and integration parameters between MCI patients with and without AD high-risk factors. We also found a significant effect of tDCS-by- ε4-allele interaction on changes in the functional segregation parameter of the temporal pole. In addition, baseline Aβ deposition significantly associated negatively with change in global functional integrity of hippocampal formation. Anodal-tDCS might help to enhance restorative and compensatory intrinsic functional changes in MCI patients, modulated by the presence of Aβ retention and the ε4-allele.
已知阳极经颅直流电刺激（anodal-tDCS）可改善轻度认知障碍（MCI）患者在静息态功能磁共振成像（fMRI）期间的认知能力，并使异常网络配置正常化。我们旨在根据阿尔茨海默病（AD）的高危因素：淀粉样β蛋白（Aβ）沉积和ε4等位基因状态，评估序贯阳极tDCS对MCI患者认知功能、功能分离和整合参数的影响。在32例MCI患者中（[F]氟代脱氧葡萄糖正电子发射断层扫描（[F] flutemetamol）阴性：n = 10，[F] flutemetamol阳性：n = 22；ε4阴性：n = 13，ε4阳性：n = 19），我们对左侧背外侧前额叶皮层进行阳极tDCS（2 mA/天，每周5次，共2周），并在刺激2周前后评估神经心理测试组和静息态fMRI测量结果。我们观察到，阳极tDCS对有无AD高危因素、Aβ潴留和ε4等位基因的MCI患者之间神经心理测试组分数变化的影响不显著。然而，有无AD高危因素的MCI患者在脑功能分离和整合参数上存在显著差异。我们还发现tDCS与ε4等位基因相互作用对颞极功能分离参数的变化有显著影响。此外，基线Aβ沉积与海马结构整体功能完整性的变化显著负相关。阳极tDCS可能有助于增强MCI患者的恢复性和代偿性内在功能变化，这种变化受Aβ潴留和ε4等位基因的影响。
