Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Institute of Biochemistry, Molecular Biology & Biotechnology, University of Colombo, Colombo, Sri Lanka.
BMC Res Notes. 2024 Aug 13;17(1):223. doi: 10.1186/s13104-024-06884-8.
To perform a comparative analysis of the extended APPROPRIATE trial of measures of reactive nitrogen species and antioxidant capacity in patients having resistant hypertension with controlled hypertension and healthy controls.
Mean serum NO- and NOx levels were significantly lower and mean AOC was significantly higher in patients with controlled hypertension (n = 38) and healthy controls (n = 38) compared to resistant hypertension (RHTN) patients (n = 40) at the pre-intervention stage (p < 0.001). The serum NO-, NOx and AOC levels of both controlled hypertension and healthy controls were comparable to those of the RHTN patients following treatment with propranolol (n = 18). Considering all samples (n = 114) we noted that there were significant weak and moderate positive correlations between NO levels with systolic blood pressure (SBP) and diastolic blood pressure (DBP) (r = 0.396, p < 0.001 and r = 0.292, p = 0.004) as well as total NOx levels with SBP and DBP (r = 0.636 and r = 0.480 respectively, p < 0.001). Conversely, there was a significant negative correlation between AOC levels with SBP and DBP (r= -0.846 and r = -0.626 respectively, p < 0.001).
对 APPROPRIATE 试验中抗高血压治疗前后患者反应性氮物种和抗氧化能力的测量结果进行比较分析，以评估抗高血压治疗的效果。
与难治性高血压患者相比，接受抗高血压治疗的患者（n=38）和健康对照组（n=38）的血清 NO-和 NOx 水平明显降低，AOC 水平明显升高（p<0.001）。经过普萘洛尔治疗后，控制高血压和健康对照组的血清 NO-、NOx 和 AOC 水平与难治性高血压患者相当（n=18）。考虑到所有样本（n=114），我们发现 NO 水平与收缩压（SBP）和舒张压（DBP）之间存在显著的弱正相关和中度正相关（r=0.396，p<0.001 和 r=0.292，p=0.004），总 NOx 水平与 SBP 和 DBP 之间也存在显著的强正相关（r=0.636 和 r=0.480，p<0.001）。相反，AOC 水平与 SBP 和 DBP 之间存在显著的负相关（r=-0.846 和 r=-0.626，p<0.001）。
