Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
CNNP Lab (www.cnnp-lab.com), Interdisciplinary Computing and Complex Biosystems Group, School of Computing, Newcastle University, Newcastle upon Tyne, UK.
Bipolar Disord. 2024 Sep;26(6):604-616. doi: 10.1111/bdi.13484. Epub 2024 Aug 13.
People with bipolar disorder (BD) tend to show widespread cognitive impairment compared to healthy controls. Impairments in processing speed (PS), attention and executive function (EF) may represent 'core' impairments that have a role in wider cognitive dysfunction. Cognitive impairments appear to relate to structural brain abnormalities in BD, but whether core deficits are related to particular brain regions is unclear and much of the research on brain-cognition associations is limited by univariate analysis and small samples.
Euthymic BD patients (n = 56) and matched healthy controls (n = 26) underwent T1-weighted MRI scans and completed neuropsychological tests of PS, attention and EF. We utilised public datasets to develop normative models of cortical thickness (n = 5977) to generate robust estimations of cortical abnormalities in patients. Canonical correlation analysis was used to assess multivariate brain-cognition associations in BD, controlling for age, sex and premorbid IQ.
BD showed impairments on tests of PS, attention and EF, and abnormal cortical thickness in several brain regions compared to healthy controls. Impairments in tests of PS and EF were most strongly associated with cortical thickness in the left inferior temporal, right entorhinal and right temporal pole areas.
Impairments in PS, attention and EF can be observed in euthymic BD and may be related to abnormal cortical thickness in temporal regions. Future research should continue to leverage normative modelling and multivariate methods to examine complex brain-cognition associations in BD. Future research may benefit from exploring covariance between traditional brain structural morphological metrics such as cortical thickness, cortical volume and surface area.
与健康对照组相比，双相情感障碍（BD）患者往往表现出广泛的认知障碍。处理速度（PS）、注意力和执行功能（EF）方面的损伤可能代表具有广泛认知功能障碍作用的“核心”损伤。认知障碍似乎与 BD 中的结构性大脑异常有关，但核心缺陷是否与特定的大脑区域有关尚不清楚，并且许多关于大脑-认知关联的研究受到单变量分析和小样本的限制。
稳定期 BD 患者（n=56）和匹配的健康对照组（n=26）接受 T1 加权 MRI 扫描，并完成 PS、注意力和 EF 的神经心理学测试。我们利用公共数据集开发皮质厚度的正态模型（n=5977），以对患者的皮质异常进行稳健估计。使用典型相关分析评估 BD 中的多变量脑-认知关联，同时控制年龄、性别和前期智商。
与健康对照组相比，BD 在 PS、注意力和 EF 测试中表现出损伤，并且大脑的几个区域出现皮质厚度异常。PS 和 EF 测试中的损伤与左颞下回、右内嗅皮层和右颞极区域的皮质厚度最密切相关。
在稳定期 BD 中可以观察到 PS、注意力和 EF 的损伤，并且可能与颞叶区域的异常皮质厚度有关。未来的研究应继续利用正态模型和多变量方法来研究 BD 中的复杂脑-认知关联。未来的研究可能受益于探索传统的大脑结构性形态学指标（如皮质厚度、皮质体积和表面积）之间的协方差。
