Avtsyn Research Institute of Human Morphology, Petrovsky Russian Research Center of Surgery, Moscow, Russia.
Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
Bull Exp Biol Med. 2024 Jul;177(3):374-378. doi: 10.1007/s10517-024-06192-y. Epub 2024 Aug 14.
The subareolar Sappey's plexus was studied using color lymphography and immunohistochemical methods with a panel of antibodies to podoplanin, smooth muscle actin, low molecular weight cytokeratin AE1/AE3, and GATA3 on archival material obtained during radical mastectomies and sectoral resections with lymph node dissection from 86 patients diagnosed with non-special type breast cancer. At the macro- and microscopic levels, the connection between the subareolar lymphatic plexus and the lymphatic system of the breast parenchyma has been demonstrated. In triple negative breast cancer with metastases to the axillary lymph nodes, the involvement of subareolar lymphatic plexus into lymphogenous metastasis to the lymph nodes of the axillary lymphatic collector was shown.
乳晕下 Sappey 丛采用彩色淋巴造影术和免疫组织化学方法研究，使用一组针对 podoplanin、平滑肌肌动蛋白、低分子量细胞角蛋白 AE1/AE3 和 GATA3 的抗体，对 86 例经根治性乳房切除术和区域性切除术获得的存档材料进行检测，这些患者均被诊断为非特殊型乳腺癌，并行淋巴结清扫。在宏观和微观水平上，已经证明了乳晕下淋巴管丛与乳腺实质淋巴管之间的联系。在腋窝淋巴结转移的三阴性乳腺癌中，乳晕下淋巴管丛参与了向腋窝淋巴结淋巴管的淋巴转移。
