Lin Qiyi, Pan Jianpeng, Wang Huaishuai, Li Yinlin, Zhuang Yixiang, Cai Zhicong, Lin Gaofeng, Liu Weibo, Xu Guoxi
Jinjiang Municipal Hospital, Department of Gastrointestinal Surgery, Quanzhou, China.
J Med Biochem. 2024 Jun 15;43(4):503-511. doi: 10.5937/jomb0-47889.
To systematically evaluate the relationship between the expression level of long noncoding RNA NEAT1 and the clinical characteristics and prognostic value of rectal cancer patients.
PubMed, EMBASE, Cochrane library database and case-control studies on the correlation between abnormal expression of lncRNA NEAT1 and prognosis of rectal cancer patients published by the American clinical trials registry before May 1, 2023 were searched. The search time was from the establishment of the database to May 30, 2023.
A total of 7 case-control studies were included, including 1063 cancer patients. The results of meta-analysis showed that the high expression of lncRNA NEAT1 was significantly correlated with the degree of differentiation [or=0.45, 95%CI=0.32-0.63, P<0.01], tumor size [or=0.59, 95%CI=0.42-0.82, P<0.01], and overall survival [HR=1.34, 95%CI=1.21-1.48, P<0.001]; However, it was not associated with gender [or=1.23, 95%CI= 0.88-1.72, P=0.23] and lymph node metastasis [or=0.87, 95%CI=0.45-1.66, P=0.67].
The high expression of lncRNA NEAT1 may be a risk factor for poor prognosis in patients with malignant tumors, and lncRNA NEAT1 can be used as a potential biomarker to evaluate its prognosis.
系统评价长链非编码RNA NEAT1的表达水平与直肠癌患者临床特征及预后价值之间的关系。
检索PubMed、EMBASE、Cochrane图书馆数据库以及美国临床试验注册中心在2023年5月1日前发表的关于lncRNA NEAT1异常表达与直肠癌患者预后相关性的病例对照研究。检索时间为各数据库建库至2023年5月30日。
共纳入7项病例对照研究，包括1063例癌症患者。荟萃分析结果显示，lncRNA NEAT1高表达与分化程度[比值比（or）=0.45，95%置信区间（CI）=0.32-0.63，P<0.01]、肿瘤大小[or=0.59，95%CI=0.42-0.82，P<0.01]及总生存期[风险比（HR）=1.34，95%CI=1.21-1.48，P<0.001]显著相关；然而，与性别[or=1.23，95%CI=0.88-1.72，P=0.23]及淋巴结转移[or=0.87，95%CI=0.45-1.66，P=0.67]无关。
lncRNA NEAT1高表达可能是恶性肿瘤患者预后不良的危险因素，lncRNA NEAT1可作为评估其预后的潜在生物标志物。
