Khan Mohammed M, Yadav Preeti, Arowolo Seun, Saidu Anne, Olaniyi Seyi A, Kaur Parvinder, Chandrasekaran Sai Harini, Varghese Jeffrin J, Omeh Chinyere K, Vijayakumar Roshini, Kashif Mohammed, Khan Saba, Alam Roshan
Basic Medical Sciences, Integral Institute of Allied Health Sciences and Research, Lucknow, IND.
General Medicine, Grant Government Medical College, Mumbai, IND.
Cureus. 2024 Jul 14;16(7):e64531. doi: 10.7759/cureus.64531. eCollection 2024 Jul.
Non-high-density lipoprotein cholesterol (non-HDL-C) levels can increase the cardiometabolic risk factors in patients with hypothyroidism, but the findings across studies have not been consistently conclusive. The aim of this study was to find the association between non-HDL-C and cardiometabolic risk factors in patients with hypothyroidism.
In this case-control study, a total of 120 subjects among which 60 diagnosed hypothyroidism patients and 60 age-matched healthy controls were enrolled, aged 30-65 years. Body mass index (BMI), waist circumference (WC), and systolic and diastolic blood pressures (SBP and DBP) were measured. Thyroid-stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), fasting blood sugar (FBS), total cholesterol (TC), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) were estimated. Low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and non-HDL-C were calculated. A p-value of <0.05 was considered statistically significant.
Mean of BMI, WC, FBS, TSH, TC, TG, non-HDL-C, LDL-C, VLDL-C, SBP, and DBP were significantly elevated in cases compared to controls (p<0.001). However, the mean of T3, T4, and HDL-C were significantly reduced in cases compared to controls (p<0.001). Non-HDL-C has shown a significant positive correlation with age (r=0.345, p<0.01), TC (r=0.451, p<0.01), TG (r=0.269, p<0.05), LDL-C (r=0.402, p<0.01), and VLDL-C (r=0.269, p<0.05) among cases. However, non-HDL-C has shown a significant negative correlation with HDL-C (r=-0.330, p<0.05) among cases. Non-HDL-C significantly predicted cardiometabolic risk in patients with hypothyroidism (F(13,46)=3.500, p<0.001).
Non-HDL-C has shown a significant association with age and lipid abnormalities in patients with hypothyroidism. Non-HDL-C significantly predicts cardiometabolic risk factors in patients with hypothyroidism.
非高密度脂蛋白胆固醇（non-HDL-C）水平会增加甲状腺功能减退患者的心脏代谢危险因素，但各项研究结果尚未始终得出一致结论。本研究的目的是找出甲状腺功能减退患者的非高密度脂蛋白胆固醇与心脏代谢危险因素之间的关联。
在这项病例对照研究中，共纳入120名受试者，其中60名诊断为甲状腺功能减退的患者和60名年龄匹配的健康对照，年龄在30至65岁之间。测量体重指数（BMI）、腰围（WC）以及收缩压和舒张压（SBP和DBP）。估算促甲状腺激素（TSH）、三碘甲状腺原氨酸（T3）、甲状腺素（T4）、空腹血糖（FBS）、总胆固醇（TC）、甘油三酯（TG）和高密度脂蛋白胆固醇（HDL-C）。计算低密度脂蛋白胆固醇（LDL-C）、极低密度脂蛋白胆固醇（VLDL-C）和非高密度脂蛋白胆固醇。p值<0.05被认为具有统计学意义。
与对照组相比，病例组的BMI、WC、FBS、TSH、TC、TG、非高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、极低密度脂蛋白胆固醇、SBP和DBP的平均值显著升高（p<0.001）。然而，与对照组相比，病例组的T3、T4和HDL-C的平均值显著降低（p<0.001）。在病例组中，非高密度脂蛋白胆固醇与年龄（r=0.345，p<0.01）、TC（r=0.451，p<0.01）、TG（r=0.269，p<0.05）、低密度脂蛋白胆固醇（r=0.402，p<0.01）和极低密度脂蛋白胆固醇（r=0.269，p<0.05）呈显著正相关。然而，在病例组中，非高密度脂蛋白胆固醇与HDL-C呈显著负相关（r=-0.330，p<0.05）。非高密度脂蛋白胆固醇显著预测了甲状腺功能减退患者的心脏代谢风险（F(13,46)=3.500，p<0.001）。
非高密度脂蛋白胆固醇在甲状腺功能减退患者中与年龄和脂质异常存在显著关联。非高密度脂蛋白胆固醇显著预测了甲状腺功能减退患者的心脏代谢危险因素。
