Chen Tong
Research and Development, Zap Surgical Systems, San Carlos, USA.
Cureus. 2024 Jul 13;16(7):e64482. doi: 10.7759/cureus.64482. eCollection 2024 Jul.
One of the recent trends in radiation therapy is to increase conformal and accurate dose delivery such as in stereotactic radiosurgery (SRS). Treating small lesions and brain disorders requires the accurate placement of small radiation fields deep inside the human cranium. To design a collimator meeting these requirements, a new numerical concept was developed, which is presented here. The algorithm proposed here can generate beam profiles of plural collimation apertures and arbitrary initial beam spot distributions in a time-efficient method. It is an ideal tool to optimize collimator design for penumbra, dose rate, and field size. The intensity of the source beam spot is divided into slices, and each slice is projected onto the treatment plane at the isocenter through the collimator apertures. The illuminated field range and intensity are determined by geometry and the intensity of that slice of beam source, respectively. By integrating the projected intensity across all the slices of the source profile, the profile on the treatment plane is obtained. The algorithm is used to generate beam profiles of a conical pencil beam collimator system and compare them to the Monte Carlo simulation as well as measurements. It can also be used to demonstrate the impact of collimator shape on the beam penumbra, dose rate, and field size. The projection integration method provides a quick and informative tool for collimator design. The results were validated with the Monte Carlo simulation and measurements. This method was demonstrated to be effective for optimizing beam characteristics.
放射治疗的最新趋势之一是提高适形和精确的剂量输送,例如在立体定向放射外科手术(SRS)中。治疗小病变和脑部疾病需要在人类颅骨深处精确放置小辐射野。为了设计满足这些要求的准直器,开发了一种新的数值概念,在此介绍。本文提出的算法可以高效地生成多个准直孔径的光束轮廓和任意初始束斑分布。它是优化准直器的半值层、剂量率和射野大小设计的理想工具。源束斑的强度被分成薄片,每个薄片通过准直器孔径投影到等中心处的治疗平面上。照射野范围和强度分别由几何形状和该束源薄片的强度决定。通过对源轮廓的所有薄片上的投影强度进行积分,可获得治疗平面上的轮廓。该算法用于生成锥形笔形束准直器系统的光束轮廓,并将其与蒙特卡罗模拟以及测量结果进行比较。它还可用于展示准直器形状对束半值层、剂量率和射野大小的影响。投影积分方法为准直器设计提供了一种快速且信息丰富的工具。结果通过蒙特卡罗模拟和测量得到了验证。该方法被证明对优化光束特性有效。