Kajabwangu Rogers, Ngonzi Joseph, Izudi Jonathan, Bazira Joel, Ssedyabane Frank, Kanyesigye Michael, Atwine Raymond, Kayondo Musa, Ankunda Rogers, Lugobe Henry Mark, Turanzomwe Stuart, Randall Thomas C, Bajunirwe Francis
Department of Obstetrics and Gynaecology, Faculty of Medicine, Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.
Department of Community Health, Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.
Gynecol Oncol Rep. 2024 Jul 20;54:101465. doi: 10.1016/j.gore.2024.101465. eCollection 2024 Aug.
To determine the association between MetS and its components with cervical cancer among women in South-western Uganda.
We conducted an unmatched case-control study on 470 participants in a 1:2 case-to-control ratio among women in southwestern Uganda. We recruited 157 women with cervical cancer as cases and 313 women without cervical cancer as controls at the Mbarara Regional Referral Hospital Cervical Cancer Clinic. We assessed for MetS using the National Cholesterol Education Programme Adult Treatment Panel III (NCEP ATP III) criteria. We used a multivariable binary logistic regression analysis to determine the association between MetS and its components with cervical cancer adjusted for potential confounders. We reported the adjusted odds ratios (aOR) and 95% confidence intervals (CI).
Cases were significantly older than controls: 52.4 ± 13.15 versus 41.9 ± 11.9 respectively, p < 0.001. We found MetS was independently associated with cervical cancer (aOR 1.66; 95 % CI 1.07-2.57). Age ≥ 50 years (aOR-2.20; 95 % CI 1.35-3.56), HIV infection (aOR 2.51, 95 % CI 1.56-4.05), increasing parity (aOR 1.16, 95 % CI 1.06-1.26), and a lack of formal education (aOR 6.41, 95 % CI, 1.33-30.86) were also associated with cervical cancer. However, none of the components of MetS was associated with cervical cancer.
In Ugandan women, MetS was associated with a higher likelihood of cervical cancer. We, therefore recommend combined screening for MetS and cervical cancer in order to reduce morbidity and mortality from both Mets and cervical cancer.
确定乌干达西南部女性中代谢综合征（MetS）及其各组分与宫颈癌之间的关联。
我们在乌干达西南部女性中进行了一项非匹配病例对照研究，按病例与对照1:2的比例选取了470名参与者。我们在姆巴拉拉地区转诊医院宫颈癌诊所招募了157名宫颈癌女性作为病例，313名无宫颈癌女性作为对照。我们使用美国国家胆固醇教育计划成人治疗专家组第三次报告（NCEP ATP III）标准评估代谢综合征。我们采用多变量二元逻辑回归分析来确定在调整潜在混杂因素后代谢综合征及其各组分与宫颈癌之间的关联。我们报告了调整后的比值比（aOR）和95%置信区间（CI）。
病例组的年龄显著大于对照组：分别为52.4 ± 13.15岁和41.9 ± 11.9岁，p < 0.001。我们发现代谢综合征与宫颈癌独立相关（aOR 1.66；95% CI 1.07 - 2.57）。年龄≥50岁（aOR 2.20；95% CI 1.35 - 3.56）、HIV感染（aOR 2.51，95% CI 1.56 - 4.05）、产次增加（aOR 1.16，95% CI 1.06 - 1.26）以及未接受正规教育（aOR 6.41，95% CI 1.33 - 30.86）也与宫颈癌相关。然而，代谢综合征的任何组分均与宫颈癌无关。
在乌干达女性中，代谢综合征与患宫颈癌的可能性较高相关。因此，我们建议联合筛查代谢综合征和宫颈癌，以降低代谢综合征和宫颈癌的发病率和死亡率。
