Department of Medical Laboratory Science, Mbarara University of Science and Technology (MUST), P.O. Box 1410, Mbarara, Uganda.
Uganda Cancer Institute (UCI), P.O. Box 3935, Kampala, Uganda.
Lipids Health Dis. 2024 Jan 6;23(1):3. doi: 10.1186/s12944-023-01997-8.
In Sub-Saharan Africa, the prevalence of dyslipidemia is on the rise, with studies showing dyslipidemia as a contributing factor to the progression of premalignant lesions to cervical cancer. In Uganda, cervical cancer and dyslipidemia are common health concerns, considering the increasing trends of dyslipidemia in the general population and inadequate information regarding dyslipidemia and cervical lesions. This study aimed to determine the prevalence of dyslipidemia and its association with precancerous and cancerous lesions of the cervix among women attending a cervical cancer clinic at the Uganda Cancer Institute.
This cross-sectional study was conducted from February to April 2022 among women with premalignant and malignant lesions of the cervix. Data on social demographics and health-seeking behaviours were collected using a pretested structured questionnaire after written informed consent had been obtained. Pap smear collection preceded visual inspection with acetic acid; cervical biopsies were collected appropriately from eligible participants; and cervical lesions were classified using the Bethesda system 2014. Serum lipids, total cholesterol (T.C.), high-density lipoprotein (HDLc), low-density lipoprotein (LDLc), and triglycerides (T.G.s) were analysed using the COBAS™ 6000 Clinical Chemistry Analyser. The associations were assessed using the chi-square test, and P ≤ 0.05 was considered statistically significant.
The overall prevalence of dyslipidemia among women with cervical lesions was 118/159 (74%), and low HDLc was the most prevalent at 64.6% (95% CI 39.0-54.3). High T.C. (P = 0.05), high T.G.s (P = 0.011), and low HDL-c (P = 0.05) showed a significant association with precancerous lesions. High LDL-c (P = 0.019), high T.G.s (P = 0.02), and high T.G.s (P < 0.001) showed a statistically significant association with cancerous lesions.
The prevalence of dyslipidemia was high, with high TC, T.G.s, and low HDL-c significantly associated with precancerous lesions. Also, elevated T.G.s and high LDLc were significantly associated with cancerous lesions. Women may benefit from dyslipidemia screening along with cervical cancer screening.
The present study builds upon previous findings suggesting a link between dyslipidemia and cervical lesions by investigating the relationship between these two factors, specifically in women of this geographical location, where we need adequate information on these associations.
在撒哈拉以南非洲，血脂异常的患病率呈上升趋势，研究表明血脂异常是导致癌前病变进展为宫颈癌的一个因素。在乌干达，宫颈癌和血脂异常是常见的健康问题，考虑到血脂异常在普通人群中的上升趋势以及有关血脂异常和宫颈病变的信息不足。本研究旨在确定在乌干达癌症研究所宫颈疾病诊所就诊的妇女中血脂异常的流行情况及其与宫颈癌前病变和癌症病变的关系。
这是一项横断面研究，于 2022 年 2 月至 4 月期间在患有宫颈前病变和恶性病变的妇女中进行。在获得书面知情同意后，使用经过预测试的结构化问卷收集了社会人口统计学和健康寻求行为的数据。巴氏涂片采集前先进行醋酸视觉检查；从符合条件的参与者中适当采集宫颈活检；并使用 2014 年 Bethesda 系统对宫颈病变进行分类。使用 COBAS 6000 临床化学分析仪分析血清脂质、总胆固醇 (T.C.)、高密度脂蛋白 (HDLc)、低密度脂蛋白 (LDLc) 和甘油三酯 (T.G.s)。使用卡方检验评估关联，P≤0.05 被认为具有统计学意义。
患有宫颈病变的妇女血脂异常总患病率为 118/159（74%），低 HDLc 患病率最高，为 64.6%（95%CI 39.0-54.3）。高 T.C.（P=0.05）、高 T.G.s（P=0.011）和低 HDL-c（P=0.05）与癌前病变有显著关联。高 LDL-c（P=0.019）、高 T.G.s（P=0.02）和高 T.G.s（P<0.001）与癌症病变有统计学显著关联。
血脂异常的患病率较高，高 TC、T.G.s 和低 HDL-c 与癌前病变显著相关。此外，T.G.s 升高和 LDLc 升高与癌症病变显著相关。女性可能受益于血脂异常筛查以及宫颈癌筛查。
本研究在前人研究表明血脂异常与宫颈病变之间存在联系的基础上，进一步调查了这两个因素之间的关系，特别是在这个地理位置的女性中，我们需要充分了解这些关联。
