在患有针对凝血因子IX的抑制剂和过敏反应的B型血友病患者中成功诱导无免疫抑制药物的免疫耐受：一例报告
Successful immunosuppressive drug-free immune tolerance induction in hemophilia B with inhibitor and anaphylaxis to factor IX: A case report.
作者信息
Palomo Bravo Ángeles, Prieto Bonilla Rosario, Bardan Rebollar Daniel, López-Jaime Francisco José, Fernández-Bello Ihosvany
机构信息
Hematology Service Hospital Regional Universitario Materno-Infantil de Málaga Málaga Spain.
Thrombosis and Hemostasis Unit, Hematology Service Hospital Regional Universitario de Málaga Málaga Spain.
出版信息
Clin Case Rep. 2024 Aug 12;12(8):e9312. doi: 10.1002/ccr3.9312. eCollection 2024 Aug.
Recommendations advise factor IX desensitization before immune tolerance induction in severe hemophilia B, supported by immunosuppression. A child with inhibitor and anaphylaxis to factor IX showed successful immunosuppression-free immune tolerance induction using very low and slowly increasing doses of a factor IX extended-half-life product. Immune tolerance to factor IX based on this protocol merits further study.
建议在免疫抑制支持下，对重度B型血友病患者进行免疫耐受诱导前先进行IX因子脱敏治疗。一名对IX因子有抑制剂和过敏反应的儿童，使用极低剂量且缓慢递增的IX因子长效产品，成功实现了无免疫抑制的免疫耐受诱导。基于该方案的IX因子免疫耐受值得进一步研究。
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