Zhang Nan, Han Ming, Zheng Qin-Wei, Zhang Meng-Yuan, Zhi Wen-Lan, Li Jing-Jing, Cui Lin-Xuan, Tian Jin-Li, Wang Yi, Fang Sheng-Quan
Department of Gastroenterology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Pharmacol. 2024 Jul 30;15:1393526. doi: 10.3389/fphar.2024.1393526. eCollection 2024.
Refractory gastroesophageal reflux disease (refractory GERD) is a heterogeneous disease characterized by unresponsiveness or poor efficacy to proton-pump inhibitors (PPIs). This chronic disorder substantially weakens patients' mental wellbeing and quality of life, increasing the financial burden on society. Multiple articles have been reported in this area. However, literature involving scientometric analysis of refractory GERD is absent. Therefore, it is necessary to understand the evolution of research themes and the main hotspots of refractory GERD through bibliometric methods.
All documents related to refractory GERD based on the WOS Core Collection from January 2000 to November 2023 were selected for analysis. Citespace V 6.1 R6, VOSviewer V 1.6.20, and Scimago Graphica V 1.0.38 were used to perform bibliometric analysis.
We collected a total of 241 research articles from 36 countries and 322 institutions, contributed by over 1,000 authors. Over the last 20 years, the number of articles in this field has increased year by year, and since 2011, the number of publications has increased dramatically, with 85.89% of the papers. These countries are led by the United States and Japan. had the highest number of citations and had the highest number of publications. Research on standardized diagnosis and management, mechanisms, novel monitoring methods, and innovative drugs and procedures for refractory GERD are the main topics and hotspots in this field. This study also found that neuroimmune interaction is closely related to refractory GERD, which may be a new direction for future mechanism research.
Our study is the first bibliometric analysis of the global literature on refractory GERD. This research provides valuable insights for researchers, enabling them to quickly understand the research frontier and hot topics of this field.
难治性胃食管反流病（难治性GERD）是一种异质性疾病，其特征是对质子泵抑制剂（PPI）无反应或疗效不佳。这种慢性疾病严重削弱了患者的心理健康和生活质量，增加了社会经济负担。该领域已有多篇文章报道。然而，缺乏关于难治性GERD的科学计量学分析的文献。因此，有必要通过文献计量学方法了解难治性GERD研究主题的演变和主要热点。
选取2000年1月至2023年11月基于Web of Science核心合集的所有与难治性GERD相关的文献进行分析。使用Citespace V 6.1 R6、VOSviewer V 1.6.20和Scimago Graphica V 1.0.38进行文献计量学分析。
我们共收集了来自36个国家和322个机构的241篇研究文章，作者超过1000人。在过去20年中，该领域的文章数量逐年增加，自2011年以来，发表数量大幅增加，占论文总数的85.89%。这些国家以美国和日本为首。 被引次数最高， 发表数量最多。难治性GERD的标准化诊断与管理、机制、新型监测方法以及创新药物和治疗手段的研究是该领域的主要主题和热点。本研究还发现神经免疫相互作用与难治性GERD密切相关，这可能是未来机制研究的一个新方向。
我们的研究是首次对难治性GERD全球文献进行的文献计量学分析。该研究为研究人员提供了有价值的见解，使他们能够快速了解该领域的研究前沿和热点话题。
