Sun Lisha, Zhang Xiaoran, Yang Jiao, Yuan Jun, Lei Xingxing
Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Diabetes Metab Syndr Obes. 2024 Aug 8;17:2967-2974. doi: 10.2147/DMSO.S471715. eCollection 2024.
Visceral fat area (VFA) levels have been found to exhibit a strong association with various conditions such as insulin resistance (IR), inflammation, oxidative stress, metabolic syndrome (MetS), hyperlipidemia, diabetes, and its vascular complications. These complications include hypertension, cardiovascular disease, diabetic retinopathy (DR), albuminuria, and cardiovascular autonomic dysfunction, which is considered one of the main types of diabetic neuropathy. This study aimed to investigate the correlation between visceral fat and peripheral neuropathy in patients with type 2 diabetes (T2DM).
A retrospective analysis of clinical data of patients diagnosed with type 2 diabetes admitted to our hospital was conducted. After excluding 28 cases, a total of 488 patients were included, divided into the group with peripheral neuropathy (207 cases) and the control group without peripheral neuropathy (281 cases). The correlation between VFA and the presence of DPN was assessed using correlation and multiple logistic regression analyses.
In terms of general information, the group with peripheral neuropathy had lower BMI but longer duration of diabetes compared to the control group. Regarding biochemical indicators, VFA were lower in the group with peripheral neuropathy, while FPG and HbA1c levels were higher (all P<0.05). Spearman correlation analysis showed a negative correlation between VFA, and the presence of peripheral neuropathy in patients with type 2 diabetes (P<0.05). Logistic regression analysis indicated that VFA, duration of diabetes, and HbA1c level were influencing factors for the occurrence of peripheral neuropathy in patients with type 2 diabetes (P<0.05).
This study revealed a correlation between visceral fat and peripheral neuropathy in patients with type 2 diabetes, highlighting the importance of monitoring visceral fat in such patients. In addition to lower levels of VFA, factors such as duration of diabetes and glycated hemoglobin (HbA1c) level were also associated with peripheral neuropathy in patients with T2DM.
已发现内脏脂肪面积（VFA）水平与多种病症密切相关，如胰岛素抵抗（IR）、炎症、氧化应激、代谢综合征（MetS）、高脂血症、糖尿病及其血管并发症。这些并发症包括高血压、心血管疾病、糖尿病视网膜病变（DR）、蛋白尿以及心血管自主神经功能障碍，后者被认为是糖尿病神经病变的主要类型之一。本研究旨在探讨2型糖尿病（T2DM）患者内脏脂肪与周围神经病变之间的相关性。
对我院收治的2型糖尿病确诊患者的临床资料进行回顾性分析。排除28例患者后，共纳入488例患者，分为周围神经病变组（207例）和无周围神经病变的对照组（281例）。采用相关性分析和多元逻辑回归分析评估VFA与糖尿病周围神经病变（DPN）存在情况之间的相关性。
在一般信息方面，与对照组相比，周围神经病变组的体重指数（BMI）较低，但糖尿病病程较长。在生化指标方面，周围神经病变组的VFA较低，而空腹血糖（FPG）和糖化血红蛋白（HbA1c）水平较高（均P<0.05）。Spearman相关性分析显示，2型糖尿病患者的VFA与周围神经病变的存在呈负相关（P<0.05）。逻辑回归分析表明，VFA、糖尿病病程和HbA1c水平是2型糖尿病患者发生周围神经病变的影响因素（P<0.05）。
本研究揭示了2型糖尿病患者内脏脂肪与周围神经病变之间的相关性，凸显了对此类患者监测内脏脂肪的重要性。除了VFA水平较低外，糖尿病病程和糖化血红蛋白（HbA1c）水平等因素也与T2DM患者的周围神经病变有关。
