Bonanni Michela, Frazzetto Marco, Nardone Annalisa, Meucci Francesco, Musto Carmine, Quaranta Gaetano, Saccà Salvatore, Bedogni Francesco, Maffeo Diego, Ugo Fabrizio, Guarracini Fabrizio, Bocuzzi Giacomo, Durante Alessandro, Granatelli Antonino, Tumminello Gabriele, Eusebio Geppina, Grasso Carmelo, De Marco Federico, Cortese Bernardo, Mariani Massimiliano, Berti Sergio
UOC Diagnostica Interventistica, Ospedale del Cuore Fondazione C.N.R. Regione Toscana G. Monasterio Massa, Massa, Italy.
Department of Biomedicine and Prevention, Policlinico Tor Vergata, Roma, Italy.
Front Cardiovasc Med. 2024 Jul 25;11:1419018. doi: 10.3389/fcvm.2024.1419018. eCollection 2024.
Recent studies have shown gender differences in cardiovascular outcomes after left atrial appendage closure (LAAC), highlighting different complication rates and adverse events, particularly in short-term assessments. As a result, there remains a significant knowledge gap on how these differences directly impact the efficacy and safety of LAAC procedures. The aim of this retrospective study was to investigate the clinical outcomes of LAAC in women and men using the Watchman FLX device.
This retrospective, multicenter study analyzes gender-specific outcomes in 650 patients who underwent LAAC with the Watchman FLX device between March 2019 and May 2022, drawn from the ITALIAN-FLX registry.
The results show comparable rates of all-cause mortality, stroke, transient ischemic attack and major bleeding in men and women 12 months after the procedure. Notably, no significant gender differences were found for periprocedural complications.
In conclusion, this study shows that LAAC with the Watchman FLX device has comparable clinical outcomes between genders at both short-term and long-term follow-up.
最近的研究表明，左心耳封堵术（LAAC）后心血管结局存在性别差异，突出了不同的并发症发生率和不良事件，尤其是在短期评估中。因此，关于这些差异如何直接影响LAAC手术的疗效和安全性，仍存在重大知识空白。这项回顾性研究的目的是使用Watchman FLX装置调查LAAC在女性和男性中的临床结局。
这项回顾性多中心研究分析了2019年3月至2022年5月期间在意大利FLX注册中心接受Watchman FLX装置LAAC的650例患者的性别特异性结局。
结果显示，术后12个月男性和女性的全因死亡率、中风、短暂性脑缺血发作和大出血发生率相当。值得注意的是，围手术期并发症未发现显著性别差异。
总之，本研究表明，使用Watchman FLX装置进行LAAC在短期和长期随访中，不同性别之间的临床结局相当。
