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人参皂苷Rg3联合近红外光热逆转乳腺癌MCF-7/ADR细胞多药耐药性

Ginsenoside Rg3 combined with near-infrared photothermal reversal of multidrug resistance in breast cancer MCF-7/ADR cells.

作者信息

Chang Ying, Fu Qiang, Lu Zhongqi, Jin Quanxin, Jin Tiefeng, Zhang Meihua

机构信息

Department of Ultrasound Medicine Affiliated Hospital of Yanbian University Yanji China.

Department of Pathology and Cancer Research Center Yanbian University Medical College Yanji China.

出版信息

Food Sci Nutr. 2024 May 21;12(8):5750-5761. doi: 10.1002/fsn3.4205. eCollection 2024 Aug.

DOI:10.1002/fsn3.4205
PMID:39139957
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11317707/
Abstract

Adriamycin (ADR) is a frequently employed chemotherapeutic agent for the management of breast cancer. Nevertheless, multidrug resistance (MDR) can impair its therapeutic efficacy in breast cancer. MDR is characterized by increased expression of the P-glycoprotein (P-gp) efflux pump, up-regulation of anti-apoptotic proteins, and downregulation of pro-apoptotic proteins. Consequently, inhibition of ATP-binding cassette (ABC) transporter proteins has been deemed the most efficacious approach to overcome MDR. In this study, we used MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide), Western blots, flow cytometry, immunofluorescence, and constructed xenograft tumors to investigate whether ginsenoside Rg3-near-infrared photothermal (Rg3-NIR) combination reversed multidrug resistance in MCF-7/ADR breast cancer. In vivo and in vitro experiments, the results showed that Rg3-NIR co-treatment was effective in inducing the apoptosis of MCF-7/ADR breast cancer cells. This was achieved by reversing the expression of drug resistance-associated proteins, while also inhibiting cell proliferation, migration, and epithelial-mesenchymal transition (EMT) processes via attenuation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway transduction. Ginsenoside Rg3 combined with near-infrared photothermal therapy (NIR) effectively reverses multidrug resistance in breast cancer MCF-7/ADR cells, providing a new therapeutic strategy for breast cancer drug resistance.

摘要

阿霉素（ADR）是一种常用于治疗乳腺癌的化疗药物。然而，多药耐药性（MDR）会削弱其在乳腺癌治疗中的疗效。MDR的特征在于P-糖蛋白（P-gp）外排泵的表达增加、抗凋亡蛋白的上调以及促凋亡蛋白的下调。因此，抑制ATP结合盒（ABC）转运蛋白被认为是克服MDR最有效的方法。在本研究中，我们使用MTT（3-[4,5-二甲基噻唑-2-基]-2,5-二苯基四氮唑溴盐）、蛋白质免疫印迹法、流式细胞术、免疫荧光，并构建异种移植肿瘤，以研究人参皂苷Rg3-近红外光热（Rg3-NIR）联合治疗是否能逆转MCF-7/ADR乳腺癌中的多药耐药性。在体内和体外实验中，结果表明Rg3-NIR联合治疗可有效诱导MCF-7/ADR乳腺癌细胞凋亡。这是通过逆转耐药相关蛋白的表达来实现的，同时还通过减弱磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（AKT）信号通路转导来抑制细胞增殖、迁移和上皮-间质转化（EMT）过程。人参皂苷Rg3联合近红外光热疗法（NIR）可有效逆转乳腺癌MCF-7/ADR细胞中的多药耐药性，为乳腺癌耐药提供了一种新的治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a02/11317707/560780e0ea91/FSN3-12-5750-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a02/11317707/04761e997eb2/FSN3-12-5750-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a02/11317707/a14b75d3b2ef/FSN3-12-5750-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a02/11317707/a7c572174af2/FSN3-12-5750-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a02/11317707/d770901d4cb1/FSN3-12-5750-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a02/11317707/d88fd2746e30/FSN3-12-5750-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a02/11317707/560780e0ea91/FSN3-12-5750-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a02/11317707/04761e997eb2/FSN3-12-5750-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a02/11317707/a14b75d3b2ef/FSN3-12-5750-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a02/11317707/a7c572174af2/FSN3-12-5750-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a02/11317707/d770901d4cb1/FSN3-12-5750-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a02/11317707/d88fd2746e30/FSN3-12-5750-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a02/11317707/560780e0ea91/FSN3-12-5750-g003.jpg

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本文引用的文献

1
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Drug Resist Updat. 2023 Nov;71:101002. doi: 10.1016/j.drup.2023.101002. Epub 2023 Aug 22.
2
Cancer statistics, 2023.癌症统计数据，2023 年。
CA Cancer J Clin. 2023 Jan;73(1):17-48. doi: 10.3322/caac.21763.
3
Anti-cancer effects of ginsenoside CK on acute myeloid leukemia in vitro and in vivo.人参皂苷CK对急性髓系白血病的体内外抗癌作用
GANT61 通过上调溶酶体活性和降低 HL-60/ADR 细胞中的 BCL2 表达来克服阿霉素耐药性。
Cancer Cell Int. 2024 Dec 26;24(1):430. doi: 10.1186/s12935-024-03626-5.
Heliyon. 2022 Dec 7;8(12):e12106. doi: 10.1016/j.heliyon.2022.e12106. eCollection 2022 Dec.
4
Near-infrared photoimmunotherapy: design and potential applications for cancer treatment and beyond.近红外光免疫治疗：癌症治疗及其他领域的设计与潜在应用。
Theranostics. 2022 Oct 9;12(16):7108-7131. doi: 10.7150/thno.74820. eCollection 2022.
5
Paclitaxel-loaded ginsenoside Rg3 liposomes for drug-resistant cancer therapy by dual targeting of the tumor microenvironment and cancer cells.载紫杉醇的人参皂苷 Rg3 脂质体通过双重靶向肿瘤微环境和癌细胞用于耐药性癌症治疗。
J Adv Res. 2023 Jul;49:159-173. doi: 10.1016/j.jare.2022.09.007. Epub 2022 Sep 24.
6
Targeting therapy and tumor microenvironment remodeling of triple-negative breast cancer by ginsenoside Rg3 based liposomes.基于人参皂苷 Rg3 的脂质体靶向治疗三阴性乳腺癌及重塑肿瘤微环境。
J Nanobiotechnology. 2022 Sep 15;20(1):414. doi: 10.1186/s12951-022-01623-2.
7
Triple negative breast cancer (TNBC): Non-genetic tumor heterogeneity and immune microenvironment: Emerging treatment options.三阴性乳腺癌（TNBC）：非遗传肿瘤异质性和免疫微环境：新兴治疗选择。
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Mol Cancer. 2022 Apr 22;21(1):103. doi: 10.1186/s12943-022-01524-w.
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Eur J Med Chem. 2022 May 5;235:114300. doi: 10.1016/j.ejmech.2022.114300. Epub 2022 Mar 18.