Al-Kufaishi Ali M A, Al-Musawi Noor J T
Department of Medical Laboratory Techniques, Al-Furat Al-Awsat Technical University/College of Health and Medical Techniques, Kufa, Iraq.
University of Babylon/DNA Research Center, Babylon , Iraq.
Horm Mol Biol Clin Investig. 2024 Aug 14;45(4):157-164. doi: 10.1515/hmbci-2024-0017. Print 2024 Dec 17.
The study involves the effect of hypothalamus-pituitary-adrenal hormones disorders, and related to oxidative stress in individuals with PTSD to those in the healthy group after they experience a specific event that results in a congenital illness or limb loss.
Obtaining serum samples from males exclusively in cases where psychiatrists have determined that the men have experienced psychological damage brought on by a particular tragedy, and testing the men for hypothalamus-pituitary-adrenal axis and oxidative stress parameters in comparison to healthy participants.
It was observed that there was a notable rise in cortisol levels (5.60 ± 0.93) at 4 pm compared with healthy control (3.43 ± 0.64) resulting from the stimulating effect of the pituitary gland, and this increase has a role in raising levels of oxidative stress in patients total oxidant status (1.08 ± 0.13) compared with control (0.70 ± 0.10). High oxidative stress may lead to increased prolactin levels and decreased testosterone levels.
Transmission of incorrect chemical signals from the central nervous system has a role in causing disturbances in hormonal levels of the hypothalamus and its associated glands, and thus an imbalance in the metabolic rate due to high cortisol. Also, high levels of prolactin hormones play a role in a significant decrease in testosterone levels.
本研究涉及下丘脑 - 垂体 - 肾上腺激素紊乱的影响，以及创伤后应激障碍（PTSD）患者在经历导致先天性疾病或肢体缺失的特定事件后，与健康组相比的氧化应激情况。
仅在精神科医生确定男性经历了特定悲剧带来的心理创伤的情况下，采集男性血清样本，并与健康参与者比较，检测这些男性的下丘脑 - 垂体 - 肾上腺轴和氧化应激参数。
观察到下午4点时，由于垂体的刺激作用，皮质醇水平（5.60±0.93）与健康对照组（3.43±0.64）相比显著升高，这种升高在提高患者氧化应激水平方面起作用，患者总氧化剂状态（1.08±0.13）与对照组（0.70±0.10）相比升高。高氧化应激可能导致催乳素水平升高和睾酮水平降低。
中枢神经系统传递错误的化学信号在导致下丘脑及其相关腺体激素水平紊乱中起作用，进而由于高皮质醇导致代谢率失衡。此外，高催乳素水平在睾酮水平显著降低中起作用。
