School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, Zhejiang 310053, China.
ACS Chem Neurosci. 2024 Sep 4;15(17):3090-3105. doi: 10.1021/acschemneuro.4c00371. Epub 2024 Aug 14.
Ischemic stroke is a serious condition that results in high rates of illness and death. Anaerobic glycolysis becomes the primary means of providing energy to the brain during periods of low oxygen levels, such as in the aftermath of an ischemic stroke. This process is essential for maintaining vital brain functions and has significant implications for recovery following a stroke. Energy supply by anaerobic glycolysis and acidosis caused by lactic acid accumulation are important pathological processes after ischemic stroke. Numerous natural products regulate glucose and lactate, which in turn modulate anaerobic glycolysis. This article focuses on the relationship between anaerobic glycolysis and ischemic stroke, as well as the associated signaling pathways and natural products that play a therapeutic role. These natural products, which can regulate anaerobic glycolysis, will provide new avenues and perspectives for the treatment of ischemic stroke in the future.
缺血性脑卒中是一种严重的疾病，会导致高发病率和死亡率。在低氧水平下，如在缺血性脑卒中后，无氧糖酵解成为大脑提供能量的主要方式。这个过程对于维持重要的大脑功能至关重要，对脑卒中后的恢复也有重要意义。无氧糖酵解和乳酸积累引起的酸中毒产生的能量供应是缺血性脑卒中后的重要病理过程。许多天然产物可调节葡萄糖和乳酸，进而调节无氧糖酵解。本文主要关注无氧糖酵解与缺血性脑卒中之间的关系，以及相关的信号通路和具有治疗作用的天然产物。这些可以调节无氧糖酵解的天然产物，将为未来治疗缺血性脑卒中提供新的途径和视角。
