Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, 430030, China.
Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, Wuhan, China.
J Neuroinflammation. 2024 Nov 28;21(1):308. doi: 10.1186/s12974-024-03303-4.
Brain takes up approximately 20% of the total body oxygen and glucose consumption due to its relatively high energy demand. Glucose is one of the major sources to generate ATP, the process of which can be realized via glycolysis, oxidative phosphorylation, pentose phosphate pathways and others. Lactate serves as a hub molecule amid these metabolic pathways, as it may function as product of glycolysis, substrate of a variety of enzymes and signal molecule. Thus, the roles of lactate in central nervous system (CNS) diseases need to be comprehensively elucidated. Histone lactylation is a novel lactate-dependent epigenetic modification that plays an important role in immune regulation and maintaining homeostasis. However, there's still a lack of studies unveiling the functions of histone lactylation in the CNS. In this review, we first comprehensively reviewed the roles lactate plays in the CNS under both physiological and pathological conditions. Subsequently, we've further discussed the functions of histone lactylation in various neurological diseases. Furthermore, future perspectives regarding histone lactylation and its therapeutic potentials in stroke are also elucidated, which may possess potential clinical applications.
由于大脑具有较高的能量需求，因此其大约占据了全身氧气和葡萄糖消耗的 20%。葡萄糖是生成三磷酸腺苷 (ATP) 的主要来源之一，其过程可以通过糖酵解、氧化磷酸化、磷酸戊糖途径等途径来实现。乳酸作为这些代谢途径中的枢纽分子，既可以作为糖酵解的产物，也可以作为多种酶的底物和信号分子。因此，需要全面阐明乳酸在中枢神经系统 (CNS) 疾病中的作用。组蛋白乳酰化是一种新型的依赖于乳酸的表观遗传修饰，在免疫调节和维持内稳态中发挥着重要作用。然而，目前仍缺乏研究揭示组蛋白乳酰化在中枢神经系统中的功能。在这篇综述中，我们首先全面综述了乳酸在生理和病理条件下在中枢神经系统中的作用。随后，我们进一步讨论了组蛋白乳酰化在各种神经疾病中的功能。此外，还阐明了组蛋白乳酰化及其在中风中的治疗潜力的未来展望，这可能具有潜在的临床应用价值。
